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Table 3 Genotype frequencies of SNPs and Hardy-Weinberg equilibrium in studied populations

From: Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development

Genotypes Control group GC patients
No. (%) HWE No. (%) HWE All type GCa
  χ2 P value χ2 P value χ2 P value
rs2273535 203 0.867 0.351 110 0.366 0.544 3.987 0.136
 AA 120 (59.1)    77 (70.0)
 AT 69 (34.0) 29 (26.4)
 TT 14 (6.9) 4 (3.6)
rs1047972 202 0.152 0.696 113 1.691 0.193 4.840 0.089
 CC 148 (73.3)    95 (84.1)
 CT 49 (24.2) 16 (14.1)
 TT 5 (2.5) 2 (1.8)
rs911160 201 0.349 0.554 116 2.815 0.093 6.233 0.044
 GG 107 (53.2)    70 (60.4)
 CG 77 (38.3) 44 (37.9)
 CC 17 (8.5) 2 (1.7)
rs8173 200 0.017 0.895 115 0.0001 0.989 8.007 0.018
 CC 97 (48.5)    39 (33.9)
 CG 84 (42.0) 56 (48.7)
 GG 19 (9.5) 20 (17.4)
rs2241909 203 1.186 0.276 115 1.065 0.302 6.201 0.102
 AA 87 (42.9)    63 (54.8)
 AG 97 (47.8) 47 (40.9)
 GG 19 (9.3) 5 (4.3)
rs2289590 200 3.523 0.060 108 1.414 0.234 20.683 < 0.001
 AA 62 (31.0)    60 (55.6)
 AC 110 (55.0) 44 (40.7)
 CC 28 (14.0) 4 (3.7)
rs758099 203 2.107 0.146 116 1.186 0.276 3.107 0.211
 CC 103 (50.8)    57 (49.2)
 CT 77 (37.9) 52 (44.8)
 TT 23 (11.3) 7 (6.0)
rs11084490 201 0.0009 0.975 115 3.038 0.083 9.083 b 0.009
 CC 121 (60.2)    83 (72.2)
 CG 70 (34.8) 32 (27.8)
 GG 10 (5.0)
rs42873 201 0.272 0.601 115 2.668 0.102 3.228 0.199
 GG 127 (63.2)    65 (56.5)
 CG 64 (31.8) 47 (40.9)
 CC 10 (5.0) 3 (2.6)
  1. Statistically significant values are highlighted in bold (P ≤ 0.05)
  2. HWE Hardy-Weinberg equilibrium, GC gastric cancer, χ2 Chi-square statistics
  3. aχ2 analysis between all type GC patients and controls
  4. bFisher statistics