Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development

Table 2 Basic information for studied polymorphisms

dbSNP	Variant location	Gene	Base change	NCBI assembly location (Build GRCh38)^a	TaqMan SNP assay ID	Tag SNP (CEU population; HapMap)^b	Minor allele frequency (MAF)^c
dbSNP	Variant location	Gene	Base change	NCBI assembly location (Build GRCh38)^a	TaqMan SNP assay ID	Tag SNP (CEU population; HapMap)^b	GC Patients	Control group	ALL	EUR	CEU
rs2273535	Missense	AURKA	A/T	Chr.20:56386485	C_25623289_10	Yes	0.168	0.238	0.310	0.216	0.177
rs1047972	Missense	AURKA	C/T	Chr.20:56386407	AHX1IRW	No	0.088	0.146	0.150	0.182	0.157
rs911160	Intron	AURKA	G/C	Chr.20:56382507	C_8947670_10	Yes	0.206	0.276	0.447	0.246	0.202
rs8173	3′ UTR	AURKA	G/C	Chr.20:56369735	C_8947675_10	No	0.417	0.305	0.486	0.282	0.232
rs2241909	Synonymous	AURKB	A/G	Chr.17:8205021	C_22272900_10	No	0.247	0.332	0.379	0.340	0.303
rs2289590	Intron	AURKB	C/A	Chr.17:8207446	C_15770418_10	Yes	0.240	0.415	0.453	0.415	0.389
rs758099	Intron	AURKC	C/T	Chr.19:57231966	C_2581008_1_	No	0.284	0.302	0.375	0.255	0.253
rs11084490	5′ UTR	AURKC	C/G	Chr.19:57231104	C_27847620_10	Yes	0.139	0.223	0.132	0.165	0.177
rs42873	Intron	PLK1	G/C	Chr.16:23683411	C_2392140_10	Yes	0.230	0.208	0.234	0.215	0.192

ALL All phase 3 individuals, EUR, European population, CEU, Utah residents with Northern and Western European ancestry, GC, Gastric cancer, UTR Untranslated region
^a https://www.lifetechnologies.com
^b https://snpinfo.niehs.nih.gov/snpinfo/snptag.html
^cMAFs extracted from 1000 Genomes Project Phase 3

ISSN: 1471-2407