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Fig. 2 | BMC Cancer

Fig. 2

From: Differential expression of N-linked oligosaccharides in methotrexate-resistant primary central nervous system lymphoma cells

Fig. 2

Expression changes of neutral and sialyl sugar chains in normal-phase HPLC analysis of the N-linked oligosaccharide patterns of human methotrexate (MTX)-resistant lymphoma cells. a–f Neutral sugar chain form HKBML (a), TK (c), and RAJI (e), and sialyl sugar chain from HKBML (b), TK (d), and RAJI (f) were examined. Intensities were evaluated with the percent (%) area of peak in fractions eluting at retention times of M4, M5, M6, M7, M8, and M9. The peak numbers refer to the oligosaccharide structures in Additional file 5: Figure S4. g Summary for expression changes of neutral and sialyl sugar chains among HKBML and TK as PCNSL, and RAJI as non-CNS lymphoma. Color configuration indicates high (red) to low (green). S0: non-sialyl sugar chain, Neu: Neuraminidase-treated sugar chains. h Summary for expression changes of sialyl sugar chains among HKBML and TK as PCNSL, and RAJI as non-CNS lymphoma. Fold changes of sialyl sugar chains from MTX-resistant cells compared to the corresponding non-resistant cells, including HKBML, TK, and RAJI. Color configuration indicates high (red) to low (green). NA, not applicable. S0: non-sialyl sugar chain, Neu: Neuraminidase-treated sugar chains

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