Fig. 6

Effects of CD73 specific inhibitor APCP and CD73 neutralizing antibody on MMP-2 production in co-cultured cells. a MMP-2 production in conditioned medium from co-cultured cells was not reduced by addition of 20–80 μM CD73 specific inhibitor adenosine 5′-(α,β-methylene) diphosphate (APCP). b Use of CD73 neutralizing antibody demonstrates apparent inhibition of MMP-2 production in conditioned medium from co-cultured cells, while control IgG did not cause any inhibition