SITE/REF. | AGE SEX | Immunosupp | CLINICAL FEATURES | HISTOLOGY | IIC/EBV/CLONALITY | STAGING THERAPY | FOLLOW-UP |
---|---|---|---|---|---|---|---|
Atrial myxoma Bagwan 2009 (ref [2]) | 81/M | negative | Multiple cerebral strokes | Foci of large lymphoid cells at myxoma surface | CD20+, CD79α+, CD10+, BCL6+, BCL2+, CD3-. Ki67:80% EBV: NV. Ig clonality NP. | NS Staging: neg; BM: neg. Surgery+ R-CHOP | NA |
Atrial myxoma Dimitrova 2010 (ref [3]) | 51/M | negative | Acute obstructive left heart failure | Foci of large lymphoid cells at myxoma surface | CD20+, CD10+. Ki67 high EBV: NV. Ig clonality NP. | Imaging/BM Staging: neg. Surgery+ CHOP (VI) | NA |
Atrial myxoma Loong 2010 (ref [4]) | 70/F | negative | Ischemic stroke | Foci of large lymphoid cells | CD20+, CD79α+, PAX5+, CD43+, MUM1+, CD10-, BCL6+, BCL2+, CD30+, CD138-, HHV8-, CD3-. Ki67 100%. LMP1+, EBNA2+, EBER+. Ig clonality +. | CT/BM Staging: neg. Surgery + R-CEOP (IV) | Died for CH complications (neutropenia+ pneumonia) at 5 mo. No autopsy |
Atrial myxoma Svec 2012 (ref [5]) | 60/F | negative | Embolic brain stroke | Foci of large lymphoid cells | CD20+, CD79α+, PAX5+, CD10-MUM1+, CD23+, BCL2+, BCL6-, CD5-, CD3-, cyclin D1-, CD138-, CD38-; Ki67: 100%. LMP1+, EBER+, EBNA2+. FISH MYC, BCL2, BCL6 -. Ig clonality NP. | CT/PET/BM Staging: neg. Surgery+ R-CHOP (VI) | NED at 7 mo |
Atrial myxoma Bartoloni 2013 (ref [6]) | 55/F | negative | Fatigue, fever | Foci of large lymphoid cells at myxoma surface | LCA+, CD20+, CD79α+, MUM1+, HHV8-, CD3-, CD5-. Ki67: 90%. LMP1+, EBNA2-, EBER+ Ig clonality NP. | CT/BM staging: neg. Surgery only | NED at 72 mo |
Atrial myxoma Aguilar 2015 (ref [7]) | 52/M | negative | Dysarthria and hemiplegia | Foci of large lymphoid cells | CD20+, CD79α+, PAX5+, CD30+, MUM1+, ALK-1-, CD10-CD43-, cyclinD1-, CD3-, LMP1+, EBNA2+, EBER+. Ig clonality +. | CT/BM staging: neg. Surgery only | NED at 42 mo |
Atrial myxoma Tapan 2015 (ref [8]) | 49/M | negative | Palpitations | Foci of large lymphoid cells | CD20+, CD79α+, CD30+, MUM1+, CD3-, CD5-, CD10-, CD138-, cyclin D1-, ALK1-, EMA-. Ki67 80%. EBNA2+, EBER+. Ig clonality NP. | NS Staging: neg; BM neg. Surgery + R-CHOP | NED at 12 mo |
Atrial myxoma Boyer 2017 (ref [9]) | 54/F | negative | Syncope | Foci of large lymphoid cells | CD20+, PAX5+, CD79α+, BCL6+, CD30+, CD10-, CD138- CD3-, HHV8-, Ki67 80%. EBER+. Ig clonality NP. | NS Staging: neg. Surgery/ Other therapy: NA | NED at 130 mo |
Atrial myxoma Boyer 2017 (ref [9]) | 55/F | negative | Syncope, cough, dyspnea | Foci of large lymphoid cells | CD20+, PAX5+, CD79α+, BCL6+, MUM1+, CD10-, CD45+, CD30+, HHV-8-, CD138-, CD3-. Ki67: > 95%. EBER+, LMP1+, EBNA2+. FISH for MYC-. Ig clonality NP. | NS Staging: neg. Surgery only | Died at 2 mo for cardiac cause. Autopsy: No lymphoma |
Atrial myxoma Boyer 2017 (ref [9]) | 54/M | negative | Dyspnea, respiratory failure | Foci of large lymphoid cells | CD20+, PAX5+, BCL6+, MUM1+, CD10-, CD38+, CD45+, CD30+, CD3-. Ki67:90% EBER+, LMP1+, EBNA2+. FISH MYC, BCL6, BCL2 -. Ig clonality NP. | CT/BM Staging: neg. Surgery only | Recurrent FA-DLBCL at mitral valve after 25 mo. Died at 26 mo (embolic stroke). No autopsy. |
Atrial myxoma Yan 2017 (ref [9]) | 54/M | negative | Congestive heart failure | Foci of large lymphoid cells within fibrin | CD20+, CD79α+, MUM1+, CD10-, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 90% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP. | CT/BM Staging: neg. Surgery only | NED at 7 MO |
Atrial myxoma Yan 2017 (ref [10]) | 61/F | negative | Congestive heart failure | Foci of large lymphoid cells within fibrin | CD20+, CD79α+, MUM1+, CD10+, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 95% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP. | CT/BM Staging: neg. Surgery only | NED at 84 mo |
Atrial myxoma Yan 2017 (ref [10]) | 46/F | negative | Congestive heart failure | Foci of large lymphoid cells within fibrin | CD20+, CD79α+, MUM1+, CD10-, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 90% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP. | CT/BM Staging: neg. Surgery only | NED at 3 mo |
Atrial myxoma Yan 2017 (ref [10]) | 46/F | negative | Congestive heart failure | Foci of large lymphoid cells within fibrin | CD20+, CD79α+, MUM1+, CD10-, BCL6-, CD30+. ALK-, BCL2-, CD3-, CD5-, Ki67 85% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP. | CT/BM Staging: neg. Surgery only | NED at 120 mo |
Atrial thrombus Qigley 2003 (ref [11]) | 29/M | negative | Cerebral embolic stroke | Foci of large lymphoid cells at clot’s surface | CD45+, CD20+, CD79α+, CD43+, CD30+, CD3, LMP -, HHV8-, EBER+. Clonality:κ rearrangement +. IGH -, TCR-. | Imaging/BM Staging: neg. Surgery+ R-CHOP (VI) | NED at 24 mo |
Atrial thrombus Gruver 2012 (ref [12]) | 56/M | negative | Short breath | Foci of large lymphoid cells within fibrin thrombus | CD20+, CD79α+, PAX5+, CD30+, CD43-, CD45+, BCL6+, MUM1+, BCL2+, CD10-, CD3-, CD5-, HHV8-, MYC + 30%; KI67 > 90% LMP1+, EBNA2 + .EBER+. Ig clonality +. | NS Staging: neg. Surgery+ R-CHOP (VI) | NED at 8 mo |
Myxomatous mitral valve Gruver 2012 (ref [12]) | 75/M | negative | Dyspnea, aortic insufficiency, mitral valve regurgitation | Foci of large lymphoid cells within fibrin on mitral valve | CD20+, CD79α+, PAX5+, CD30-, CD43-, CD45+, BCL6-, MUM1+, BCL2+, CD10-, CD3-, CD5-, HHV8-, MYC -. KI67100%. LMP1-, EBNA2-. EBER-. Ig clonality +. | NS Staging: neg. Surgery+R-CVP (I) + R-CHOP (VI) | NED at 39 mo |
Prosthesis (knee) Cheuk 2005 (ref [13]) | 78/M | negative | Pain at knee prosthesis (implanted 22 yrs. before) | Foci of large lymphoid cells within fibrin and necrosis | CD20+, CD79α+, CD138+/−. CD2-, CD3-, CD5-, CD10-, BCL6-, HHV8-. Ki67:70%. LMP1+, EBER+. Ig clonality +. | NS Staging: neg. Surgery+RT | NED at 24 mo |
Prosthesis (aortic valve) Bagwan 2009 (ref [2]) | 50/M | negative | Symptoms of aortic regurgitation. Aortic valve prosthesis (16 yrs. before) | Foci of large lymphoid cells within aortic valve leaflets | CD45+, CD20+, CD79α+, CD10+, BC6+/−, BCL2+/−, Ki67:80% LMP1-. Ig clonality: NP. | NS Staging: neg; BM: neg. Surgery+ R-CHOP | Died after 6mo for prosthesis rupture. Autopsy: no lymphoma |
Prosthesis (aortic valve) Berrio 2010 (ref [14]) | 60/M | negative | Acute left heart failure. History of aortic valve prosthesis for stenosis | Foci of large lymphoid cells within valve vegetations | CD20+, CD43+, CD3-. Ki67:80–90% EBV: NV. Ig clonality: NP. | NS Staging: neg. Surgery only | Died for tricuspidal endocarditis, pneumonia 2 yrs. later. No autopsy. |
Prosthesis (aortic graft) Miller 2010 (ref [15]) | 48/M | negative | Ischemic attack. Marfan sy. Asc.a. aneurysm graft+ aortic valve prosthesis (24 yrs. before) | Foci of large lymphoid cells within fibrin | CD20+, MUM1+, CD10-, BCL6- BCL2+, CD3-, HHV8-. EBER+. Ig clonality +. | CT/PET/BM Staging: neg. Surgery only | NED at 6 mo |
Prosthesis (aortic valve) Miller 2010 (ref [15]) | 80/F | negative | Heart failure. Aortic valve prosthesis (8 yrs. before) | Foci of large lymphoid cells within fibrin | CD20+, MUM1+, CD10-, BCL6-BCL2-, CD3-, HHV8-, EBER+. Ig clonality +. | CT/PET/BM Staging: neg. Surgery only | Died (for breast cancer 18 mo after aortic valve surgery). No autopsy. |
Prosthesis (aortic graft) Miller 2010 (ref [15]) | 79/F | negative | Short breath, thoracic pulsing sensation. Tube graft for asc. a. dissection (5 yrs. before) | Foci of large lymphoid cells within fibrin | CD20+, MUM1+, CD10-, BCL6+, BCL2+, CD3-, HHV8-, EBER+, Ig clonality +. | CT/PET/BM Staging: neg. Surgery only | Died for surgical complications. No autopsy |
Prosthesis (aortic graft) Gruver 2012 (ref [12]) | 55/M | negative | Stroke. Aortic graft for aneurysm (4 yrs. before) | Foci of large lymphoid cells within thrombus | CD20+, CD79α+, PAX5+, CD30+, CD43+, CD45+, BCL6+, MUM1+, BCL2-, CD10-, CD3-, CD5-, HHV8-, MYC-; KI67 100%. LMP1+, EBNA2 + .EBER+. Ig clonality +. | NS Staging: neg. Surgery + R-CEOP (VIII) | NED at 16 mo |
Prosthesis (vascular graft) Boyer 2017 (ref [9]) | 56/M | negative | IR aorta+ CIA aneurysms. TAA aneurysm graft + thrombectomy (1 yr. before). Asc a. dissection graft (9 yrs. before). | Foci of large lymphoid cells within thrombus of IR aorta and CIA aneurysms. In retrospect foci within thrombus of TAA aneurysm | CD20+, PAX5+, BCL6-, MUM1+, CD10-, CD138-, HHV8-, CD30+, KI67: 95%. EBER+, LMP1+, EBNA2+. FISH for MYC -. Ig clonality +. | CT/PET/BM Staging: neg. Surgery+ R-CHOP (VI) + IT MTX | AWSD at 24 mo. Surgical revision of aortic graft: persistent foci of EBV+ large B cell. |
Prosthesis (vascular graft) Boyer 2017 (ref [9]) | 68/M | negative | Lower limbs ischemia. AA aneurysm repair with IR graft (7 yrs. before). | Foci of large lymphoid cells within thrombus | CD20+, PAX5+, BCL6+, CD10-MUM1+, CD30+, HHV8-, KI67 90%, EBER+, LMP1+, EBNA2+. FISH for MYC -. Ig clonality NP. | CT/PET Staging neg. 3 mo after: PET/CT/biopsy: foci of EBV+ cells near adrenal gland. R-COEP (II) | Died at 10 mo for embolic stroke. No progressive lymphoma. No autopsy |
Prosthesis (vascular) Boyer 2017 (ref [9]) | 71/M | MG for THY treated with surgery+ steroids+ AZA | AF graft (6 yrs. before). | Foci of large lymphoid cells within thrombus associated with graft | CD20+, CD79α+, PAX5+, CD10-BCL6+, MUM1+, CD30+, CD45+, CD138-, HHV8-, KI67 > 95%, EBER+, LMP1+. Ig clonality +. | NS Staging: neg. Surgery only | NED at 10 mo |
Pseudocyst (kidney) Lee 2009 (ref [16]) | 61/M | negative | Renal cyst (for 20 yrs) | Foci of large lymphoid cells within necrosis | CD22+, CD45+, CD79α+, MUM1+, PAX5+, CD3-, CD10-, CD20-, CD138-, BCL6-, ALK1-, HHV8-, κ-, λ-, EBER+. Ig clonality NP. | Staging NA. Surgery+ CHOP (VI) | NA |
Pseudocyst (spleen) Loong 2010 (ref [4]) | 29/M | negative | Abdominal pain | Foci of large lymphoid cells within necrosis | CD20+, CD79α+, PAX5+, CD43+, MUM1+, CD10-, BCL6-CD138-, BCL2+, CD30-, HHV8-, CD3-. Ki67 90%. LMP1+, EBNA2+, EBER+. Ig clonality +. | PET/BM Staging: neg. Surgery (splenectomy) + R (IV) | NED at 6 mo |
Pseudocyst (kidney) Valli 2011 (ref [17]) | 46/M | negative | Left-sided flank pain | Foci of large lymphoid cells within necrosis | CD20+, MUM1+, CD10-, BCL6-BCL2+, CD30-, HHV8-;Ki67:90%. EBER+. Ig clonality NP. | CT/PET/BM Staging: neg. Surgery+ R-CHOP (VI) | NED at 1 mo |
Pseudocyst (adrenal gland) Boroumand 2012 (ref [18]) | 63/F | negative | Right abdominal pain | Foci of large lymphoid cells within fibrin | CD20+, CD79α+, PAX5+, MUM1+, BCL2+, CD3-, CD10-, CD30-, BCL6-, HHV8-. Ki67 > 90%. LMP1-; EBER+. Ig clonality NP. | NS Staging: neg. Surgery + R-CHOP (VI) + RT | NED at 40 mo |
Pseudocyst (testis) Boroumand 2012 (ref [18]) | 27/M | negative | R. scrotal swelling. Herniorraphy followed by l. scrotal hematoma (removed 3 yrs. before) | Foci of large lymphoid cells within fibrin | CD20+, CD79α+, CD30+, MUM1+, BCL2+, CD3-, CD10- BCL6-, HHV8-. Ki67 > 90%. LMP1+, EBER+. Ig clonality NP. | NS Staging: neg. Surgery only | NED at 9 mo |
Pseudocyst (spleen) Boyer 2017 (ref [9]) | 37/F | negative | Splenic mass (9 cm), incidentally found | Foci of large lymphoid cells within fibrin | CD20+, PAX5+, MUM1+, CD10-BCL6-, CD30-, CD45+, KI67 > 90% EBER+. Ig clonality NP. | CT/PET/BM Staging: neg. Surgery + R-CHOP (III) | NED at 32 mo |
Pseudocyst (retrop.) Boyer 2017 (ref [9]) | 73/M | negative | Femoral a. aneurysm repair | Foci of large lymphoid cells within fibrin | CD20+, PAX5+, CD79α+, BCL6-, CD10-, MUM1+, CD30+, CD45+, HHV8-, KI67 > 95%, EBER+. Ig clonality NP. | CT/BM Staging: neg. Surgery+ R-CHOP (VI) | NED at 43 mo |
Pseudocyst (adrenal gland) Boyer 2017 (ref [9]) | 70/M | negative | Adrenal mass (7 cm) causing bladder obstruction | Foci of large lymphoid cells within fibrin | CD20-, PAX5+, CD79α+, BCL6-, CD10-, MUM1+, CD45+, CD30+, CD138-, HHV8-, KI67 > 90%, LMP1-, EBNA2+, EBER+. FISH for MYC -. Ig clonality NP. | CT/PET Staging: neg. Surgery only | NED at 14 mo |
Pseudocyst (retrop.) Boyer 2017 (ref [9]) | 44/M | negative | Right flank pain | Foci of large lymphoid cells within fibrin | CD20+, PAX5+, CD10-, BCL6-, MUM1+, CD45+, CD30-, KI67 40%, LMP1+, EBNA2+, EBER+, FISH for MYC -. Ig clonality +. | BM/imaging Staging: neg. 5-CHOP | NED at 84 mo |
Pseudocyst (adrenal gland) Zanelli 2019 (ref [19]) | 71/F | negative | Lower limbs edema+ abdominal distension | Foci of large lymphoid cells within fibrin | CD20+, PAX5+, CD30+, MUM1+, CD10-, BCL6-, EBER+, Ki67 90%. Ig clonality NP. | CT Staging: neg. Surgery only | NED at 6 mo |
Teratoma (ovary) Valli 2014 (ref [20]) | 56/F | negative | Abdominal pain+ swelling | Foci of large lymphoid cells | CD20+, MUM1+, CD45+, PAX5+, CD30-, BCL6-, CD10-, CD3-, CD2-, HHV8-, CD138-. Ki67: 80%. EBER+. Ig clonality +. | CT/PET Staging: neg. Surgery+ R-CHOP (VI) | NED at 8 mo |
Hydrocele (testis) Loong 2010 (ref [4]) | 88/M | negative | Fever, scrotal pain, swelling | Foci of large lymphoid cells within necrosis | CD20+, CD79α+, PAX5+, MUM1+, CD10-, BCL6-, CD138-, BCL2+, CD30-, HHV8-, CD3+, CD2-, CD5-, CD7-. Ki67 70% LMP1+, EBNA2+, EBER+. Ig clonality -. | Staging NA. Surgery only (Orchidectomy) | NA |
Hematoma (testis) Boyer 2017 (ref [9]) | 79/M | negative | Testicular trauma (5 yrs. before) | Foci of large lymphoid cells within hematoma | CD20+, PAX5+, CD79α+, CD10-CD138-, BCL6-, MUM1+, CD45+, CD30+, HHV8-, KI67 > 90%, EBER+, LMP1+, EBNA2+. Ig clonality +. | NS Staging: neg. Surgery only | NED. Died at 17 mo |
Hematoma (thigh) Hayes 2014 (ref [21]) | 91/M | negative | Thigh hematoma. (6 yrs. before leg amputation for popl. a. aneurysm rupture at prior artery bypass graft site) | Foci of large lymphoid cells | CD45+, CD20+, MUM1+, CD30+, CD43+, BCL2+/−, MYC+, p53+/−, HHV8-, CD3-, CD5-, CD10-, BCL1-, BCL6-. Ki67: 90%. LMP1-, EBER+. Ig clonality NP. | NS Staging: neg. Surgery only | NED at 18 mo |
Subdural hematoma Reyes 1990 (ref [22]) | 56/M | negative | Headaches, dizziness, unsteady gait | Foci of large lymphoid cells within fibrin, clots, necrosis | B-cell phenotype. EBV NV. Ig clonality NP. | CT/BM Staging: neg. Surgery only | NA |
Subdural hematoma Sugita 2012 (ref [23]) | 77/M | negative | Dementia due to head trauma (20 yrs. before) | Foci of large lymphoid cells | CD20+, CD79α+, MUM1+, CD3-, BCL6-, CD10-. Ki67 high. EBNA2+, LMP1-, EBER+. Ig clonality - (rare neoplastic foci). | Imaging Staging: neg. Surgery only | NA |
Subdural hematoma Kameda 2015 (ref [24]) | 96/M | negative | Gait disturbs+ anorexia. Trauma+ subdural hematoma (7 mo before). | Brain mass: DLBCL EBV+. Subdural hematoma: FA-DLBCL. No continuity among 2 lesions | CD20+, CD79α+, CD3-, CD4-, CD7-, CD8-, LMP1+, EBNA2+, EBER+. Ig clonality NP. | CT Staging: neg at presentation. Brain mass + subdural hematoma resection. IT MTX + cytarabine+ glucocorticoids | Died after 3 mo for lymphoma dissemination. No autopsy |
Subdural hematoma Boyer 2017 (ref [9]) | 25/M | negative | SD hematoma since child. Hydrocephalus+ SD catheter. Steroid tp for pituitary overactivity | Foci of large lymphoid cells within hematoma | CD20+, PAX5+, MUM1+, CD10-BCL6-, CD30+, HHV8-, KI67 > 90%; EBER+, LMP1+. Ig clonality NP. | CT/PET/BM Staging: neg. Surgery only | NED at 7 mo |
Arachnoid cyst Kirshenbaum 2017 (ref [25]) | 81/M | negative | Tremor, gait ataxia, memory disturbs | Foci of large lymphoid cells within fibrin | CD20+ CD30+, BCL2+, MUM1+, BCL6+/−, CD10-, TdT-, CD5-, cMYC+ (50%) Ki67: > 80%. EBER+. FISH MYC -. Ig clonality +. | CT/PET staging: neg. Surgery (cyst excision) + R-lenalidomide | NA |
Cerebral artery aneurysm Present case | 64/F | negative | Cerebral hemorrhage. Left middle cerebral artery aneurysm | Foci of large lymphoid cells within fibrin | CD20+/−, PAX5+, CD79α+, CD30+, MUM1+, CD10-, BCL6-, EBER+, Ki67 90%. Ig clonality NP. | CT/BM Staging: neg. Surgery only | NED at 5 mo |