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Table 3 (Chemo-)radiation treatment details

From: Study protocols of three parallel phase 1 trials combining radical radiotherapy with the PARP inhibitor olaparib

 

Radiation target volumes

Radiation dose

Boost / Elective fields

Chemotherapy

NSCLC trial

Primary lung tumour and involved regional lymph nodes

66 Gy in 24 fractions

N.A.

Cisplatin 6 mg/m2 1.5–2 h before radiation on every radiotherapy day#

Breast cancer trial

Whole breast and involved regional lymph node areas

46.69 Gy in 23 fractions

SIB of 14.49 Gy in 23 fractions to macroscopic tumour in breast; sequential boost of 10 Gy in 5 fractions to macroscopic lymph nodes (only if applicable)

N.A.

HNSCC trial

Primary tumour and regional metastatic lymph nodes; elective lymph node volumes based on site of primary tumour and stage

70 Gy in 35 fractions

Elective fields: 46 Gy in 23 fractions (sequential boost technique) or 54.25 Gy in 35 fractions (SIB technique)

N.A.

  1. # in the CCRT arm only. Gy = Gray. N.A. = not applicable, SIB = simultaneous integrated boost