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Table 5 Age-adjusted Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between parity and breast cancer as defined by gene-specific promoter methylation (comparing case women with and without methylated breast cancer [N = 855]), Long Island Breast Cancer Study Project

From: Reproductive characteristics are associated with gene-specific promoter methylation status in breast cancer

 

Parous

Nulliparous

Gene promoter

Methylated/Unmethylated

OR

95% CI

Methylated/Unmethylated

OR

95% CI

APC

331/357

1.00

reference

56/56

1.10

0.74–1.64

BRCA1

431/302

1.00

reference

73/45

1.11

0.75–1.66

CDH1

39/629

1.00

reference

5/93

0.87

0.33–2.27

CCND2

135/532

1.00

reference

15/83

0.75

0.42–1.35

DAPK

95/572

1.00

reference

13/85

0.97

0.52–1.82

ESR1

330/395

1.00

reference

53/65

0.98

0.66–1.45

GSTP1

184/483

1.00

reference

29/69

1.11

0.69–1.76

HIN

414/253

1.00

reference

67/31

1.32

0.84–2.08

P16

27/640

1.00

reference

3/107

not estimateda

PGR

87/646

1.00

reference

15/103

1.07

0.60–1.93

RARB

183/484

1.00

reference

28/70

1.08

0.68–1.74

RASSF1A

566/101

1.00

reference

86/12

1.34

0.70–2.55

TWIST1

98/569

1.00

reference

18/80

1.36

0.78–2.38

  1. aPoint estimate was not calculated because cell sizes less than five
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BMC Cancer

ISSN: 1471-2407

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