Table 2 Age-adjusted Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between age at menarche and breast cancer defined by gene-specific promoter methylation (comparing case women with and without methylated breast cancer [N = 855]), Long Island Breast Cancer Study Project
|  | Over 12 years of age | 12 years of age or younger | ||||
|---|---|---|---|---|---|---|
Gene promoter | Methylated/Unmethylated | OR | 95% CI | Methylated/Unmethylated | OR | 95% CI |
APC | 207/235 | 1.00 | reference | 177/172 | 1.17 | 0.89–1.55 |
BRCA1 | 290/180 | 1.00 | reference | 208/163 | 0.79 | 0.60–1.04 |
CDH1 | 23/403 | 1.00 | reference | 20/311 | 1.13 | 0.61–2.09 |
CCND2 | 83/343 | 1.00 | reference | 65/266 | 1.03 | 0.71–1.48 |
DAPK | 61/365 | 1.00 | reference | 46/285 | 0.98 | 0.65–1.49 |
ESR1 | 215/251 | 1.00 | reference | 162/205 | 0.92 | 0.70–1.22 |
GSTP1 | 115/311 | 1.00 | reference | 97/234 | 1.12 | 0.82–1.54 |
HIN | 268/158 | 1.00 | reference | 208/123 | 1.00 | 0.74–1.34 |
P16 | 14/413 | 1.00 | reference | 16/325 | 1.45 | 0.70–3.02 |
PGR | 50/420 | 1.00 | reference | 49/322 | 1.28 | 0.84–1.94 |
RARB | 123/303 | 1.00 | reference | 85/246 | 0.86 | 0.62–1.18 |
RASSF1A | 363/63 | 1.00 | reference | 281/50 | 0.98 | 0.66–1.47 |
TWIST1 | 62/364 | 1.00 | reference | 53/278 | 1.13 | 0.76–1.69 |