Fig. 3From: Shaping the regulation of the p53 mRNA tumour suppressor: the co-evolution of genetic signaturesModel of the p53 translating ribosome formed by MDM2, following DNA damage. The interactions of MDM2 with the ribosomal proteins RPL5 and RPL11 (highlighted in yellow colour), are required for the phosphorylation of the nascent p53 peptide by ATM, leading to its stabilisation and activation towards the DNA damage responseBack to article page