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Table 2 Multivariable analysis for progression-free survival

From: Ten-year follow-up results of perioperative chemotherapy with doxorubicin and ifosfamide for high-grade soft-tissue sarcoma of the extremities: Japan Clinical Oncology Group study JCOG0304

Multivariable

Factors

Category

Multivariable analysis (including all variables)

  

HR (95% CI)

p-value

Sex

Female (vs. Male)

0.70 (0.29–1.72)

0.44

Age (Years)

≥40 (vs. < 40)

1.47 (0.47–4.58)

0.50

Performance Status

1 (vs. 0)

1.41 (0.56–3.59)

0.47

Histological subtype

Leiomyosarcoma (vs. UPS)

0.61 (0.17–2.18)

0.44

 

Synovial sarcoma (vs. UPS)

0.48 (0.13–1.80)

0.28

 

Others (vs. UPS)

0.65 (0.22–1.87)

0.42

Histological grade (FNCLCC)

Grade 3 (vs. 2)

0.56 (0.17–1.87)

0.34

Histological grade (Ki-67)

Grade 3 (vs. 2)

1.72 (0.51–5.80)

0.39

Tumor size

> 10 cm (vs. < 10 cm)

2.85 (1.18–6.92)

0.0203

Factors

Category

Multivariable analysis (backward elimination with alpha = 20%)

  

HR (95% CI)

p-value

Sex

Female (vs. Male)

  

Age (Years)

≥40 (vs. < 40)

  

Performance Status

1 (vs. 0)

  

Histological subtype

Leiomyosarcoma (vs. UPS)

  
 

Synovial sarcoma (vs. UPS)

  
 

Others (vs. UPS)

  

Histological grade (FNCLCC)

Grade 3 (vs. 2)

0.42 (0.13–1.34)

0.14

Histological grade (Ki-67)

Grade 3 (vs. 2)

2.39 (0.75–7.62)

0.14

Tumor size

> 10 cm (vs. < 10 cm)

3.27 (1.41–7.59)

0.0057

  1. Abbreviations: HR hazard ratio, CI confidence interval, UPS undifferentiated pleomorphic sarcoma, FNCLCC French Federation of Cancer Center