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Table 3 Multivariate analyses

From: Maximal standard uptake values of 18F-fluoro-2-deoxy-D-glucose positron emission tomography compared with Epstein-Barr virus DNA as prognostic indicators in de novo metastatic nasopharyngeal carcinoma patients

  Model 1 Model 2 Model 3
Characteristic HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value
SUVmax-T   NS   NS   NS
SUVmax-N 1.40(0.95–2.06) 0.087   NS   NS
SUVmax-M 1.72(1.13–2.78) 0.012 1.72(1.10–2.67) 0.017   NS
EBV-DNA    1.62(1.08–2.43) 0.020 1.55(1.03–2.32) 0.036
Metastatic site       
 Lung vs. Bone      0.74(0.38–1.41) 0.357
 Liver vs. Bone      1.10(0.52–2.32) 0.805
 Distant nodes vs. Bone      0.50(0.18–1.39) 0.184
 Multiple vs. Bone      1.87(1.25–2.80) 0.002
LRRT      0.51(0.35–0.78) < 0.001
  1. Abbreviations: NS non-significant, HR hazard ratio, CI confidence interval, LRRT locoregional radiotherapy
  2. Backward step-wise multivariate analyses using Cox proportional hazard model was applied to select variables. Only variables that were significant associated with overall survival are presented
  3. HRs were calculated for SUVmax-T (> 17.0 vs. ≤17.0); SUVmax-N (> 12.7 vs. ≤12.7); SUVmax-M (> 6.9 vs. ≤6.9); EBV DNA (> 13,800 copies/ml vs. ≤13,800 copies/ml); LRRT (Yes vs. No)