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Table 5 Factors affecting OS by Cox’s proportional hazards regression analysis

From: Circ-SMARCA5 suppresses progression of multiple myeloma by targeting miR-767-5p

Items

Cox’s regression model

p value

HR

95%CI

Lower

Higher

Univariate Cox’s regression

 Circ-SMARCA5 (high vs low)

0.001

0.259

0.119

0.565

 Age (≥60 years vs < 60 years)

0.545

1.238

0.620

2.472

 Gender (male vs female)

0.074

0.535

0.269

1.064

Immunoglobulin subtype

 IgG vs others

0.805

1.091

0.546

2.179

 IgA vs others

0.936

0.966

0.418

2.231

 IgM vs others

0.609

0.048

0.000

5345.739

 IgD vs others

0.837

1.233

0.168

9.065

 Bence-Jones protein vs others

0.959

0.977

0.403

2.369

 Hb (≥10 g/dL vs < 10 g/dL)

0.616

1.193

0.600

2.371

 Calcium ≥11.5 mg/dL vs < 11.5 mg/dL)

0.507

1.286

0.611

2.705

 Scr (≥2 mg/dL vs < 2 mg/dL)

0.858

1.085

0.445

2.645

 ALB (≥3.5 mg/dL vs < 3.5 mg/dL)

0.887

0.947

0.448

2.001

 β2-MG (≥5.5 mg/L vs < 5.5 mg/L)

< 0.001

108.139

14.142

826.884

 LDH (≥220 U/L vs < 220 U/L)

0.385

1.370

0.673

2.789

 Durie-Salmon stage (III vs I&II)

0.287

1.465

0.725

2.959

 ISS stage (III vs I&II)

< 0.001

108.139

14.142

826.884

 Bone lesion (yes vs no)

0.687

0.854

0.395

1.842

Cytogenetics abnormality

 t (4; 14) translocation (yes vs no)

0.747

0.822

0.250

2.706

 t (14; 16) translocation (yes vs no)

0.465

0.642

0.196

2.106

 Del (17p) (yes vs no)

0.575

1.314

0.506

3.408

Multivariate Cox’s regression with Forward Stepwise (Conditional) method

 Circ-SMARCA5 (high vs low)

0.038

0.345

0.127

0.941

 Durie-Salmon stage (III vs I&II)

0.015

2.586

1.206

5.546

 ISS stage (III vs I&II)

< 0.001

148.290

17.354

1267.115

  1. Factors affecting OS were determined by univariate and multivariate Cox’s proportional hazards regression analyses, and the multivariate Cox’s proportional hazards regression analysis was performed with Forward Stepwise (Conditional) method. p value < 0.05 was considered significant (in bold)
  2. OS overall survival, HR hazard ratio, CI confidence interval, Ig immunoglobulin, Hb hemoglobin, Scr serum creatinine, ALB albumin, β2-MG Beta-2-microglobulin, LDH lactate dehydrogenase, ISS International Staging System