Circ-SMARCA5 suppresses progression of multiple myeloma by targeting miR-767-5p

BMC Cancer

Table 3 Factors affecting CR by logistic regression analysis

Factors	Logistic regression model
	p value	OR	95%CI
	p value	OR	Lower	Higher
Univariate logistic regression
Circ-SMARCA5 (high vs low)	0.049	2.597	1.006	6.707
Age (≥60 years vs < 60 years)	0.278	0.603	0.242	1.502
Gender (male vs female)	0.822	0.900	0.359	2.257
Immunoglobulin subtype
IgG vs others	0.369	1.530	0.605	3.867
IgA vs others	0.150	0.383	0.104	1.413
IgM vs others	1.000	0.000	0.000	–
IgD vs others	0.406	3.292	0.198	54.631
Bence-Jones protein vs others	0.777	1.179	0.378	3.674
Hb (≥10 g/dL vs < 10 g/dL)	0.101	0.460	0.182	1.164
Calcium ≥11.5 mg/dL vs < 11.5 mg/dL)	0.391	0.620	0.208	1.848
Scr (≥2 mg/dL vs < 2 mg/dL)	0.484	1.441	0.517	4.014
ALB (≥3.5 mg/dL vs < 3.5 mg/dL)	0.362	1.613	0.577	4.511
β2-MG (≥5.5 mg/L vs < 5.5 mg/L)	0.034	0.332	0.120	0.918
LDH (≥220 U/L vs < 220 U/L)	0.198	0.491	0.166	1.451
Durie-Salmon stage (III vs I&II)	0.233	1.743	0.700	4.343
ISS stage (III vs I&II)	0.034	0.332	0.120	0.918
Bone lesion (yes vs no)	0.942	1.038	0.382	2.816
Cytogenetics abnormality
t (4; 14) translocation (yes vs no)	0.767	0.783	0.155	3.951
t (14; 16) translocation (yes vs no)	0.709	0.773	0.200	2.991
Del (17p) (yes vs no)	0.377	0.493	0.103	2.368
Multivariate logistic regression with Forward Stepwise (Conditional) method
ISS stage (III vs I&II)	0.034	0.332	0.120	0.918

Factors affecting CR were determined by univariate and multivariate logistic regression analyses, and the multivariate logistic regression analysis was performed with Forward Stepwise (Conditional) method. p value < 0.05 was considered significant (in bold)
CR complete remission, OR odds ratio, CI confidence interval, Ig immunoglobulin, Hb hemoglobin, Scr serum creatinine, ALB albumin, β2-MG Beta-2-microglobulin, LDH lactate dehydrogenase, ISS International Staging System

ISSN: 1471-2407