Fig. 7

Effect of Circ-SMARCA5 on cell proliferation and apoptosis in the rescue experiment. Cell proliferation was promoted in miR-767 (+) group compared with Control (+) group as well as in SMARCA5 (+)/miR-767 (+) group compared with SMARCA5 (+) group (a). Cell apoptosis rate was decreased in miR-767 (+) group compared with Control (+) group as well as in SMARCA5 (+)/miR-767 (+) group compared with SMARCA5 (+) group (b, d). The expression of cell apoptotic marker Cleaved Caspase 3 was reduced in miR-767 (+) group compared with Control (+) group but raised in SMARCA5 (+)/miR-767 (+) group compared with SMARCA5 (+) group, and for Bcl-2, its expression was promoted in miR-767 (+) group compared with Control (+) group as well as in SMARCA5 (+)/miR-767 (+) group compared with SMARCA5 (+) group (c). Comparisons of cell proliferation ability and apoptosis rate were by t test, and P < 0.05 was considered significant. **P < 0.01. Round dot represented Control (+) group, square represented miR-767 (+) group, regular triangle represented SMARCA5 (+), inverted triangle represented SMARCA5 (+)/miR-767 (+) group. Circ-SMARCA5, Circular RNA SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; miR, micro RNA; Control (+), blank overexpression; miR-767 (+), miR-767-5p overexpression; SMARCA5 (+), Circ-SMARCA5 overexpression; SMARCA5 (+)/miR-767 (+), miR-767-5p overexpression & Circ-SMARCA5 overexpression