Fig. 5

Effects of inhibitory short peptides on the invasion and metastatic colonization of ovarian cancer cells. A. SK-OV3 and HEY cells were treated by TAT-fused peptides (TAT-p + p-8 or TAT-SH3–2) for 24 h before LPA-stimulation. Matrigel invasion assay was performed to test the suppressive capabilities of these inhibitory short peptides on cell invasion. Effect of inhibitory peptides on peritoneal metastatic colonization of ovarian cancer cells. B and C. SK-OV3 or HEY cells were intraperitoneally injected into nu/nu mice. Seventy-two hrs after injection, mice were intraperitoneally injected with PBS, TAT-fused scramble peptides or TAT-p + p-8 every 2 days for four weeks, respectively. By comparing the weight of metastatic implants from animals receiving inhibitory short peptides to those receiving PBS or scrambled control peptides, we estimated the capability of inhibitory short peptides in suppressing the metastasis of ovarian cancer cells