No evidence for changes in skeletal muscle mass or weight during first-line chemotherapy for metastatic colorectal cancer

Table 3 Changes in body weight, tissue areas and muscle density during 4 months of follow-up, by gender. Fifty-seven patients were included in body composition changes analysis

	Visit	LS Means [95% CI]	LS Means [95% CI] - Women	LS Means [95% CI] - Men
Weight (kg)	T0	67.04 [64.42; 69.66]	57.57 [53.89. 61.25]	76.51 [72.83. 80.19]
	T2	66.49 [63.86; 69.11]	57.01 [53.33. 60.70]	75.96 [72.28. 79.64]
	T4	67.20 [64.57, 69.84]	57.73 [54.04. 61.42]	76.68 [72.99. 80.37]
SMM (cm²)	T0	127.83 [122.47; 133.19]	99.23 [91.96; 106.51]	156.42 [149.14; 163.70]
	T2	127.17 [121.74; 132.59]	98.57 [91.26; 105.89]	155.76 [148.43; 163.10]
	T4	130.36 [124.60; 136.12]	101.76 [94.11; 109.42]	158.95 [151.45; 166.45]
SMD (HU)	T0	40.20 [37.84; 42.56]	39.90 [36.56; 43.23]	40.51 [37.17; 43.85]
	T2	40.27 [37.84; 42.71]	40.29 [36.91; 43.67]	40.26 [36.76; 43.76]
	T4	37.18 [34.41; 39.94]	33.52 [29.38; 37.65]^a	40.86 [37.16; 44.51]
VAT (cm²)	T0	99.86 [83.92; 115.80]	59.77 [37.58; 81.96]	139.95 [117.76; 162.14]
	T2	102.48 [86.48; 118.47]	62.39 [40.16; 84.61]	142.57 [120.33; 164.80]
	T4	108.56 [92.15; 124.96]	68.46 [45.84; 91.09]	148.65 [126.22; 171.07]
SAT (cm²)	T0	137.32 [122.65; 152.00]	139.30 [118.57; 160.03]	135.34 [114.57; 156.11]
	T2	134.95 [120.23; 149.67]	134.74 [113.98; 155.51]	135.15 [114.29; 156.01]
	T4	132.75 [117.69; 147.80]	123.85 [102.34; 145.36]^b	141.64 [120.58; 162.70]

For each body component, the fitted model contained only gender and visit
LS lean square means, CI Confidence Interval, SMM skeletal muscle mass index (cm²), SMD skeletal muscle density, HU Hounsfield Unit, VAT visceral adipose tissue (cm²), SAT subcutaneous adipose tissue (cm²)
^aP = 0.038; ^bP = 0.030

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