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Table 3 Univariable and multivariable survival analysis for COL3A1, GPR158 and PITHD1 expression and overall and disease-specific survival. COL3A1 is adjusted for histotype, age, stage, CA125 and ploidy. GPR158 and PITHD1 are adjusted for age, stage, CA125 and ploidy. Significant values are marked in bold

From: Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian carcinomas

 

Overall survival

Disease-specific survival

HR (95% CI)

P value

C-index

HR (95% CI)

P value

C-index

Univariable analysis

 Histotype

0.55

0.541

0.020

0.620

 Patient age

1.018

0.038

0.568

0.99

0.48

0.530

 Stage

1.11

0.67

0.512

2.0

0.016

0.583

 CA125

0.25

0.550

0.69

0.533

 Ploidy

0.06

0.561

0.36

0.551

 COL3A1

2.99

0.026

0.537

1.51

0.43

0.520

Multivariable analysis

 COL3A1

3.20

0.032

0.654

1.40

0.56

0.704

Univariable analysis

 Patient age

1.02

0.18

0.591

0.98

0.46

0.598

 Stage

1.07

0.89

0.450

4.57

0.068

0.684

 CA125

0.97

0.493

0.45

0.642

 Ploidy

0.59

0.569

0.23

0.689

 GPR158

6.13

0.00043

0.690

0.029

0.748

Multivariable analysis

 GPR158

23.83

0.00011

0.795

1.0

0.946

Univariable analysis

 Patient age

1.021

0.22

0.569

1.014

0.48

0.548

 Stage

1.04

0.94

0.505

0.73

0.68

0.522

 CA125

0.57

0.558

0.22

0.601

 Ploidy

0.23

0.542

0.12

0.560

 PITHD1

0.22

0.012

0.558

0.17

0.003

0.574

Multivariable analysis

 PITHD1

0.082

0.0013

0.694

0.047

0.00036

0.733