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Table 3 Univariable and multivariable survival analysis for COL3A1, GPR158 and PITHD1 expression and overall and disease-specific survival. COL3A1 is adjusted for histotype, age, stage, CA125 and ploidy. GPR158 and PITHD1 are adjusted for age, stage, CA125 and ploidy. Significant values are marked in bold

From: Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian carcinomas

  Overall survival Disease-specific survival
HR (95% CI) P value C-index HR (95% CI) P value C-index
Univariable analysis
 Histotype 0.55 0.541 0.020 0.620
 Patient age 1.018 0.038 0.568 0.99 0.48 0.530
 Stage 1.11 0.67 0.512 2.0 0.016 0.583
 CA125 0.25 0.550 0.69 0.533
 Ploidy 0.06 0.561 0.36 0.551
 COL3A1 2.99 0.026 0.537 1.51 0.43 0.520
Multivariable analysis
 COL3A1 3.20 0.032 0.654 1.40 0.56 0.704
Univariable analysis
 Patient age 1.02 0.18 0.591 0.98 0.46 0.598
 Stage 1.07 0.89 0.450 4.57 0.068 0.684
 CA125 0.97 0.493 0.45 0.642
 Ploidy 0.59 0.569 0.23 0.689
 GPR158 6.13 0.00043 0.690 0.029 0.748
Multivariable analysis
 GPR158 23.83 0.00011 0.795 1.0 0.946
Univariable analysis
 Patient age 1.021 0.22 0.569 1.014 0.48 0.548
 Stage 1.04 0.94 0.505 0.73 0.68 0.522
 CA125 0.57 0.558 0.22 0.601
 Ploidy 0.23 0.542 0.12 0.560
 PITHD1 0.22 0.012 0.558 0.17 0.003 0.574
Multivariable analysis
 PITHD1 0.082 0.0013 0.694 0.047 0.00036 0.733