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Table 3 Multivariate analysis of overall survival and disease-free survival

From: The effect of metformin use on hypopharyngeal squamous cell carcinoma in diabetes mellitus patients

Comparison Overall survival Disease-free survival
OR(95% CI) p OR(95% CI) p
Early stage
 DM vs. non DM 1.67 (0.17–2.59) 0.56 1.25 (0.33–4.73) 0.73
 DM (metformin) vs. DM (no metformin) 1.54 (0.32–7.22) 0.58 1.44 (0.09–2.14) 0.31
 DM (no metformin) vs. non DM 0.62 (0.12–3.06) 0.55 1.75 (0.34–8.79) 0.49
 DM (metformin) vs. non DM 1.95 (0.23–4.10) 0.96 1.78 (0.18–3.28) 0.73
Late stage
 DM vs. non DM 1.25 (0.53–2.93) 0.61 1.70 (0.29–1.67) 0.42
 DM (metformin) vs. DM (no metformin) 4.28 (1.45–12.65) 0.01* 1.23 (0.07–0.68) 0.01*
 DM (no metformin) vs. non DM 1.56 (0.18–1.66) 0.29 1.57 (0.52–4.71) 0.41
 DM (metformin) vs. non DM 2.40 (0.91–6.35) 0.07 1.36 (0.13–0.98) 0.04*
  1. * p < 0.05
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