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Table 2 Subgroup analysis of association between the expression of miR-221 and OS

From: Prognostic value of miR-221 in human malignancy: evidence from 3041 subjects

Categories Subgroups No of studies Pool HR 95% CI Result I2 P
All OS 22 1.93 1.43–2.60 S 80.4% 0.000
Countries Asian (Chinese) 16 2.14 1.53–2.99 S 74.2% 0.000
Non-Asian 6 1.44 0.83–2.47 NS 83.3% 0.000
Samples origins Tumor tissues 13 1.61 1.13–2.29 S 81.4% 0.000
Serum/blood 7 3.25 2.15–4.92 S 42.2% 0.109
Marrow 2 1.07 0.26–4.43 NS 85.4% 0.009
Sample sizes > 100 7 2.28 1.29–4.11 S 85.9% 0.000
≤100 15 1.80 1.25–2.59 S 78.4% 0.000
Cancer types Colon cancer 4 2.33 1.60–3.38 S 0.0% 0.897
Liver cancer 5 1.91 1.53–2.38 S 0.0% 0.633
Lung cancer 2 2.02 1.45–2.81 S 0.0% 0.486
ALL 2 1.07 0.26–4.43 NS 85.4% 0.009
Breast cancer 2 2.02 0.22–18.81 NS 91.7% 0.001
Osteosarcoma 2 2.24 0.23–22.29 NS 93.7% 0.000
Ovarian cancer 2 0.94 0.17–5.17 NS 91.8% 0.000
  1. Note: ALL Acute lymphoid leukemia; S Significant; NS Non-significant