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Table 2 Subgroup analysis of association between the expression of miR-221 and OS

From: Prognostic value of miR-221 in human malignancy: evidence from 3041 subjects

Categories

Subgroups

No of studies

Pool HR

95% CI

Result

I2

P

All

OS

22

1.93

1.43–2.60

S

80.4%

0.000

Countries

Asian (Chinese)

16

2.14

1.53–2.99

S

74.2%

0.000

Non-Asian

6

1.44

0.83–2.47

NS

83.3%

0.000

Samples origins

Tumor tissues

13

1.61

1.13–2.29

S

81.4%

0.000

Serum/blood

7

3.25

2.15–4.92

S

42.2%

0.109

Marrow

2

1.07

0.26–4.43

NS

85.4%

0.009

Sample sizes

> 100

7

2.28

1.29–4.11

S

85.9%

0.000

≤100

15

1.80

1.25–2.59

S

78.4%

0.000

Cancer types

Colon cancer

4

2.33

1.60–3.38

S

0.0%

0.897

Liver cancer

5

1.91

1.53–2.38

S

0.0%

0.633

Lung cancer

2

2.02

1.45–2.81

S

0.0%

0.486

ALL

2

1.07

0.26–4.43

NS

85.4%

0.009

Breast cancer

2

2.02

0.22–18.81

NS

91.7%

0.001

Osteosarcoma

2

2.24

0.23–22.29

NS

93.7%

0.000

Ovarian cancer

2

0.94

0.17–5.17

NS

91.8%

0.000

  1. Note: ALL Acute lymphoid leukemia; S Significant; NS Non-significant