From: CA19–9 decrease and survival according to platelet level in patients with advanced pancreatic cancer
No. of cases | No. of events | PFS per unit decrease of CA19–9† | No. of events | OS per unit decrease of CA19–9† | |||
---|---|---|---|---|---|---|---|
Univariate HR (95% CI) | Multivariate HR* (95% CI) | Univariate HR (95% CI) | Multivariate HR* (95% CI) | ||||
Total patients | 200 | 183 | 0.86 (0.78–0.95) | 0.85 (0.77–0.94) | 155 | 0.87 (0.79–0.96) | 0.83 (0.74–0.93) |
Baseline platelet level | |||||||
Tertile 1 (lowest) | 66 | 59 | 0.69 (0.55–0.85) | 0.51 (0.38–0.69) | 50 | 0.57 (0.45–0.73) | 0.45 (0.33–0.62) |
Tertile 2 | 67 | 64 | 0.75 (0.50–1.14) | 0.85 (0.54–1.35) | 52 | 0.72 (0.51–1.03) | 0.74 (0.50–1.09) |
Tertile 3 (highest) | 67 | 60 | 0.90 (0.79–1.03) | 0.88 (0.75–1.02) | 53 | 0.93 (0.80–1.08) | 0.94 (0.74–1.10) |
Pinteraction‡ | 0.026 | 0.034 | 0.001 | < 0.001 |