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Table 3 multivariable covariate-adjusted Cox models for overall survival for stage ‘IV’ colorectal cancer

From: Impact of prior malignancies on outcome of colorectal cancer; revisiting clinical trial eligibility criteria

Patient characteristics

Stage IV colorectal All-cause HRa(95% CI)b

Stage IV All-cause P valuec

Prior cancer diagnosis (vs none)

 Prior non-leukemic malignancies

.998 (.966 to 1.031)

.907

 Prior leukemias

1.535 (1.303 to 1.809)

<.001

Age (vs 20–65), y

 < 20

.851 (.644 to 1.124)

.255

 > 65

1.452 (1.429 to 1.475)

<.001

Sex (vs female)

 Male

1.060 (1.044 to 1.076)

<.001

Race (vs white)

 Black

1.095 (1.071 to 1.120)

<.001

 Others

.892 (.867 to .918)

<.001

Marital status (vs single)

 Married

.920 (.899 to .940)

<.001

 Separated

1.092 (1.025 to 1.164)

.007

 Divorced

.959 (.929 to .990)

.010

 Widowed

1.120 (1.090 to 1.150)

<.001

Grade (Vs Well Differentiated)

 Moderately Differentiated

1.125 (1.094 to 1.157)

<.001

 Poorly Differentiated

1.596 (1.550 to 1.644)

<.001

 Undifferentiated and Anaplastic

1.833 (1.738 to 1.932)

<.001

Radiation (Vs No)

 Yes

.690 (.674 to .707)

<.001

Surgery (Vs No)

 Yes

.471 (.462 to .480)

<.001

 Ablation

.979 (.808 to 1.185)

.825

  1. athis number represent the hazard ratio for all cause death for the above coverables. All statistical tests were tow-sided
  2. bthis represents confidence interval
  3. cTwo-sided P value was calculated from multivariable covariate-adjusted Cox models