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Table 3 multivariable covariate-adjusted Cox models for overall survival for stage ‘IV’ colorectal cancer

From: Impact of prior malignancies on outcome of colorectal cancer; revisiting clinical trial eligibility criteria

Patient characteristics Stage IV colorectal All-cause HRa(95% CI)b Stage IV All-cause P valuec
Prior cancer diagnosis (vs none)
 Prior non-leukemic malignancies .998 (.966 to 1.031) .907
 Prior leukemias 1.535 (1.303 to 1.809) <.001
Age (vs 20–65), y
 < 20 .851 (.644 to 1.124) .255
 > 65 1.452 (1.429 to 1.475) <.001
Sex (vs female)
 Male 1.060 (1.044 to 1.076) <.001
Race (vs white)
 Black 1.095 (1.071 to 1.120) <.001
 Others .892 (.867 to .918) <.001
Marital status (vs single)
 Married .920 (.899 to .940) <.001
 Separated 1.092 (1.025 to 1.164) .007
 Divorced .959 (.929 to .990) .010
 Widowed 1.120 (1.090 to 1.150) <.001
Grade (Vs Well Differentiated)
 Moderately Differentiated 1.125 (1.094 to 1.157) <.001
 Poorly Differentiated 1.596 (1.550 to 1.644) <.001
 Undifferentiated and Anaplastic 1.833 (1.738 to 1.932) <.001
Radiation (Vs No)
 Yes .690 (.674 to .707) <.001
Surgery (Vs No)
 Yes .471 (.462 to .480) <.001
 Ablation .979 (.808 to 1.185) .825
  1. athis number represent the hazard ratio for all cause death for the above coverables. All statistical tests were tow-sided
  2. bthis represents confidence interval
  3. cTwo-sided P value was calculated from multivariable covariate-adjusted Cox models
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