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Table 2 Multivariable covariate-adjusted Cox models for colorectal cancer-specific survival

From: Impact of prior malignancies on outcome of colorectal cancer; revisiting clinical trial eligibility criteria

Patient characteristics

Colorectal cancer–specific HRa (95% CI)b

Colorectal cancer–specific P valuec

Prior cancer diagnosis (vs none)

 Prior non-leukemic malignancies

.930 (.909 to .952)

<.001

 Prior leukemias

1.263 (1.116 to 1.430)

<.001

Age (vs 20–65), y

 < 20

.931 (.748 to 1.158)

.531

 > 65

1.376 (1.361 to 1.392)

<.001

Sex (vs female)

 Male

1.124 (1.112 to 1.136)

<.001

Race (vs white)

 Black

1.135 (1.116 to 1.154)

<.001

 Others

.872 (.854 to .890)

<.001

Marital status (vs single)

 Married

.895 (.880 to .910)

<.001

 Separated

1.116 (1.066 to 1.168)

<.001

 Divorced

.942 (.920 to .965)

<.001

 Widowed

1.108 (1.087 to 1.129)

<.001

Stage (VS Localized)

 Regional

2.983 (2.937 to 3.029)

<.001

 Distant

13.548 (13.331 to 13.769)

<.001

Grade (Vs Well Differentiated)

 Moderately Differentiated

1.153 (1.132 to 1.174)

<.001

 Poorly Differentiated

1.668 (1.634 to 1.701)

<.001

 Undifferentiated and Anaplastic

1.904 (1.828 to 1.983)

<.001

Radiation (Vs No)

 Yes

1.019 (1.004 to 1.034)

.011

Surgery (Vs No)

 Yes

.434 (.427 to .442)

<.001

 Ablation

1.058 (.918 to 1.219)

.435

  1. athis number represent the hazard ratio for all cause and colorectal cancer specific death for the above coverables. All statistical tests were tow-sided
  2. bthis represents confidence interval
  3. cTwo-sided P value was calculated from multivariable covariate-adjusted Cox models