From: Prognostic significance of helicobacter pylori-infection in gastric diffuse large B-cell lymphoma
Patients | Number of patients n = 129 | Number of event n = 28 | Median PFS | 95% CI | Actuarial 5-year progression-free survival (%) | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | ||||||
Gender | |||||||||
Female | 66 | 15 | 79.2 | 70.1–88.3 | 78.0 | 1 | 0.691 | – | |
Male | 63 | 13 | 94.0 | 83.4–104.6 | 81.8 | 0.860(0.409–1.809) | – | ||
Age, years | |||||||||
< 60 | 73 | 12 | 96.4 | 86.9–105.9 | 87.7 | 1 | 0.098 | 1 | 0.871 |
≥ 60 | 56 | 16 | 85.6 | 73.1–98.1 | 70.1 | 1.886(0.889–4.003) | 1.078(0.435–2.671) | ||
Presence of B symptoms | |||||||||
No | 84 | 13 | 99.5 | 91.3–107.6 | 86.5 | 1 | 0.012 | 1 | 0.004 |
Yes | 45 | 15 | 66.3 | 54.8–77.7 | 68.1 | 2.605(1.235–5.493) | 3.337(1.466–7.595) | ||
Tumor sites | |||||||||
Proximal | 11 | 4 | 55.0 | 34.8–75.2 | 49.1 | 1 | 0.213 | – | |
Distal | 71 | 16 | 91.1 | 80.5–101.8 | 78.9 | 0.495(0.164–1.495) | – | ||
Lugano stage | |||||||||
I/II | 88 | 14 | 98.2 | 89.6–106.8 | 85.1 | 1 | 0.013 | 1 | 0.666 |
IIE/IV | 41 | 14 | 66.4 | 53.4–79.3 | 69.1 | 2.573(1.222–5.417) | 1.129(0.651–1.960) | ||
IPI risk group | |||||||||
Low (intermediate) risk | 109 | 17 | 102.1 | 95.3–108.9 | 85.3 | 1 | < 0.001 | 1 | 0.117 |
High (intermediate) risk | 20 | 11 | 58.5 | 39.4–77.6 | 50.0 | 4.364(2.033–9.366) | 2.924(0.764–11.186) | ||
ECOG | |||||||||
0–1 | 117 | 19 | 97.8 | 90.3–105.4 | 85.3 | 1 | < 0.001 | 1 | 0.001 |
≥ 2 | 12 | 9 | 30.7 | 12.0–49.3 | 27.8 | 8.190(3.644–18.407) | 5.002(1.970–12.698) | ||
Surgical treatment | |||||||||
No | 87 | 22 | 68.1 | 61.0–75.2 | 76.0 | 1 | 0.044 | 1 | 0.068 |
Yes | 42 | 6 | 102.0 | 91.7–112.4 | 87.6 | 0.384(0.152–0.974) | 0.381(0.135–1.075) | ||
Histological analyses | |||||||||
non-GCB | 56 | 11 | 77.0 | 67.9–86.1 | 85.6 | 1 | 0.702 | – | |
GCB | 24 | 6 | 76.6 | 62.8–90.5 | 70.5 | 1.214(0.448–3.290) | – | ||
Lactate dehydrogenase | |||||||||
< 220 U/L | 92 | 16 | 96.6 | 87.9–105.3 | 82.9 | 1 | 0.059 | 1 | 0.646 |
≥ 220 U/L | 37 | 12 | 69.8 | 56.7–82.9 | 72.8 | 2.059(0.973–4.357) | 1.108(0.716–1.713) | ||
H. pylori status | |||||||||
Negative | 73 | 22 | 85.0 | 74.2–95.7 | 74.1 | 1 | 0.040 | 1 | 0.045 |
Positive | 56 | 6 | 100.6 | 92.0–109.2 | 89.3 | 0.388(0.157–0.959) | 0.379(0.147–0.978) |