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Table 2 Univariate and multivariate analysis of prognostic factors for progression-free survival in 129 patients with de novo gastric diffuse large B-cell lymphoma

From: Prognostic significance of helicobacter pylori-infection in gastric diffuse large B-cell lymphoma

Patients

Number of patients n = 129

Number of event n = 28

Median PFS

95% CI

Actuarial 5-year progression-free survival (%)

Univariate analysis

Multivariate analysis

HR (95% CI)

p

HR (95% CI)

p

Gender

 Female

66

15

79.2

70.1–88.3

78.0

1

0.691

 Male

63

13

94.0

83.4–104.6

81.8

0.860(0.409–1.809)

Age, years

  < 60

73

12

96.4

86.9–105.9

87.7

1

0.098

1

0.871

  ≥ 60

56

16

85.6

73.1–98.1

70.1

1.886(0.889–4.003)

1.078(0.435–2.671)

Presence of B symptoms

 No

84

13

99.5

91.3–107.6

86.5

1

0.012

1

0.004

 Yes

45

15

66.3

54.8–77.7

68.1

2.605(1.235–5.493)

3.337(1.466–7.595)

Tumor sites

 Proximal

11

4

55.0

34.8–75.2

49.1

1

0.213

 Distal

71

16

91.1

80.5–101.8

78.9

0.495(0.164–1.495)

Lugano stage

 I/II

88

14

98.2

89.6–106.8

85.1

1

0.013

1

0.666

 IIE/IV

41

14

66.4

53.4–79.3

69.1

2.573(1.222–5.417)

1.129(0.651–1.960)

IPI risk group

 Low (intermediate) risk

109

17

102.1

95.3–108.9

85.3

1

< 0.001

1

0.117

 High (intermediate) risk

20

11

58.5

39.4–77.6

50.0

4.364(2.033–9.366)

2.924(0.764–11.186)

ECOG

 0–1

117

19

97.8

90.3–105.4

85.3

1

< 0.001

1

0.001

  ≥ 2

12

9

30.7

12.0–49.3

27.8

8.190(3.644–18.407)

5.002(1.970–12.698)

Surgical treatment

 No

87

22

68.1

61.0–75.2

76.0

1

0.044

1

0.068

 Yes

42

6

102.0

91.7–112.4

87.6

0.384(0.152–0.974)

0.381(0.135–1.075)

Histological analyses

 non-GCB

56

11

77.0

67.9–86.1

85.6

1

0.702

 GCB

24

6

76.6

62.8–90.5

70.5

1.214(0.448–3.290)

Lactate dehydrogenase

  < 220 U/L

92

16

96.6

87.9–105.3

82.9

1

0.059

1

0.646

  ≥ 220 U/L

37

12

69.8

56.7–82.9

72.8

2.059(0.973–4.357)

1.108(0.716–1.713)

H. pylori status

 Negative

73

22

85.0

74.2–95.7

74.1

1

0.040

1

0.045

 Positive

56

6

100.6

92.0–109.2

89.3

0.388(0.157–0.959)

0.379(0.147–0.978)

  1. The P-values with statistical significance are shown in bold