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Table 4 Univariate and multivariate Cox regression analysis of DMFS

From: Biologically effective dose (BED) of stereotactic body radiation therapy (SBRT) was an important factor of therapeutic efficacy in patients with hepatocellular carcinoma (≤5 cm)

  Univariate Cox regression Multivariate Cox regression
Patient details p value Hazard ratio (95% CI) p value Hazard ratio (95% CI)
Sex (male/female) 0.114 1.801 (0.868–3.736)   
Age 0.777 0.995 (0.964–1.028)   
Hepatitis type (B/C/alcoholic/others) 0.080 1.668 (0.940–1.028)   
Maximum tumor diameter 0.901 1.017 (0.780–1.326)   
ECOG 0.220 1.799 (0.704–4.594)   
AFP 0.471 1.000 (1.000–1.000)   
Child-Pugh score (5/6) 0.054 2.214 (0.996–4.965) 0.021 2.653 (1.160–6.067)
ALBI grade 0.487 0.714 (0.277–1.843)   
WBC count 0.061 0.854 (0.724–1.007)   
PLT count 0.320 0.997 (0.992–1.003)   
Residual normal liver volume 0.982 1.000 (0.998–1.002)   
Mean dose of whole liver volume minus GTV 0.898 0.993 (0.886–1.112)   
D700 0.496 1.064 (0.889–1.274)   
BED10 of PTV 0.013 0.964 (0.937–0.992) 0.006 0.959 (0.932–0.988)
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