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Table 4 Subgroup analysis for studies included in the analysis

From: First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis

Prostate cancer risk No. of studies Pooled RR (95% CI) I2 statistics (%) P-value for the heterogeneity Q test
First degree relatives with BCa 13 1.18(1.12,1.25) 28.70% 0.156
 Cohort 5 1.19(1.12,1.26) 53.70% 0.071
 Case-control 7 1.26(1.04,1.53) 6.90% 0.375
 Cross section 1 1.04(0.84,1.29)
 European 4 1.12(1.08,1.16) 0.00% 0.624
 American 7 1.21(1.15,1.27) 0.00% 0.618
 Asian 2 2.58(1.21,5.54) 0.00% 0.472
Adjustment for other factors
 Yes 10 1.17(1.10,1.24) 25.30% 0.210
 No 3 1.23(1.13,1.34) 0.00% 0.383
 BCa diagnosis at age ≥ 50 2 1.06(0.83,1.37) 45.00% 0.179
 BCa diagnosis at age <50 2 1.40(0.99,1.98) 40.00% 0.195
Mother with BCa 11 1.19(1.10,1.28) 0.00% 0.686
 Cohort 5 1.21(1.11,1.31) 0.00% 0.671
 Case-control 5 1.14(0.85,1.54) 7.30% 0.365
 Cross section 1 1.07(0.80,1.43)
 European 2 1.09(0.77,1.54) 0.00% 0.549
 American 8 1.19(1.10,1.29) 0.00% 0.480
 Asian 1 2.01(0.28,14.40)
Adjustment for other factors
 Yes 8 1.19(1.10,1.28) 0.10% 0.428
 No 3 1.32(0.75,2.32) 0.00% 0.873
 Sister with BCa 10 1.25(1.09,1.44) 43.00% 0.071
 Cohort 4 1.15(1.04,1.28) 8.40% 0.351
 Case-control 5 1.75(1.14,2.70) 50.00% 0.091
 Cross section 1 1.30(0.95,1.78)
 European 2 1.21(0.93,1.58) 0.00% 0.567
 American 7 1.26(1.07,1.50) 55.60% 0.035
 Asian 1 4.03(0.73,22.19)
Adjustment for other factors
 Yes 8 1.24(1.06,1.44) 48.80% 0.057
 No 2 1.66(0.66,4.18) 39.20% 0.200
 Daughter with BCa 4 1.74(0.74,4.12) 43.70% 0.149
 Cohort 1 1.45(1.04,2.03) 8.40% 0.351
 Case-control 3 2.27(0.44,11.75) 62.50% 0.046
 European 2 3.74(0.39,35.97) 79.50% 0.027
 American 1 1.01(0.19,5.28)
 Asian 1 1.01(0.18,5.54)
Adjustment for other factors
 Yes 2 3.66(0.26,52.14) 75.30% 0.044
 No 2 1.43(1.03,1.99) 0.00% 0.685
  1. BCa: breast cancer; PCa: prostate cancer