Table 3 GRADE assessment of quality of the body of evidence, and summary of findings
Association studied | No. of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | Factors that can increase quality of evidence | Pooled effect estimate | Quality |
|---|---|---|---|---|---|---|---|---|---|
Family history of BCa in first degree relatives and risk of PCa | 13 | Observational study | Not serious | Not serious | Not serious | Not serious | All plausible confounding would reduce a demonstrated effect | 1.14(1.10,1.18) | ⨁⨁⨁◯MODERATE |
Family history of BCa in mothers and risk of PCa | 11 | Observational study | Not serious | Not serious | Not serious | Not serious | All plausible confounding would reduce a demonstrated effect | 1.19(1.10,1.28) | ⨁⨁⨁◯MODERATE |
Family history of BCa in sisters and risk of PCa | 10 | Observational study | Not serious | Not serious | Not serious | Not serious | All plausible confounding would reduce a demonstrated effect | 1.16(1.06,1.27) | ⨁⨁⨁◯MODERATE |
Family history of BCa in daughters and risk of PCa | 4 | Observational study | Not serious | Not serious | Not serious | Not serious | All plausible confounding would reduce a demonstrated effect | 1.74(0.74,1.42) | ⨁⨁⨁◯MODERATE |
Family history of BCa in first degree relatives and risk of lethal PCa | 2 | Observational study | Not serious | Not serious | Not serious | Not serious | None | 1.18(1.04,1.34) | ⨁⨁◯ ◯LOW |
Family history of BCa in mothers and risk of lethal PCa | 2 | Observational study | Not serious | Not serious | Not serious | Not serious | None | 1.35(1.14,1.61) | ⨁⨁◯ ◯LOW |
Family history of BCa in sisters and risk of lethal PCa | 2 | Observational study | Not serious | Not serious | Not serious | Not serious | None | 1.02(0.84,1.23) | ⨁⨁◯ ◯LOW |