From: A multi-disciplinary model of survivorship care following definitive chemoradiation for anal cancer
Study | Era | No. patients | Median time to fracture/total follow-up | Median total dose (Gray) | Disease site | Study Incidencea | 5-year actuarial incidenceb |
---|---|---|---|---|---|---|---|
Bazire et al. [72] 2017 | 2007–2014 | 341 | 11 mo./38 mo. | 50.3 | 52% cervical 32% endometrial 16% anal | 4.4% Radiographic (R) | Not given |
3.2% Symptomatic (S) | |||||||
Shih et al. [73] 2013 | 2000–2008 37% IMRT | 222 | 12 mo./47 mo. | 50.4 | 65% endometrial 35% cervical | 5.0% (R) | 5.1% (R) |
3.2% (S) | |||||||
Uezono et al. [74] 2013 | 2003–2009 | 99 | 14 mo./21 mo. | 50.4 | cervical | 33% (R) | 63% (R) |
20% (S) | |||||||
Kim et al. [75] 2012 | 1998–2007 | 492 | 46 mo./42 mo. | 50.4 | rectal | 7.1% sacral fracture (R) | Not given |
Tokumaru et al. [76] 2012 | 2004–2007 | 59 | not given/24 mo. | 49 | cervical | 36%(R) | Not given |
15% (S) | |||||||
Schmeler et al. [77] 2010 | 2001–2006 3% IMRT | 300 | 14 mo./21 mo. | 45 | cervical | 9.7% (R) | Not given |
4.3% (S) | |||||||
Herman et al. [78] 2009 | 1989–2004 | 562 | 17 mo./49 mo. | 45 | rectal | 2.7% sacral fracture (R) | Not given |
1.2% sacral fracture (S) | |||||||
Oh et al. [79] 2008 | 1998–2005 | 557 | 13 mo./30 mo. | 45 | cervical | 15%(R) | 20% (R) |
8.6% (S) | 11% (S) | ||||||
Kwon et al. [80] 2008 | 1998–2005 | 510 | 17 mo./14 mo. | 50.4 | cervical | 20% (R) | 45% (R) |
8.4% (S) | |||||||
Ikushima et al. [81] 2006 | 1993–2004 | 158 | 6 mo./43 mo. | 45 | 96% cervical 4% endometrial | 11% (S) | 13% (S) |
Baxter et al. [82] 2005 | 1986–1999 | 399 women age 65+ | not given/47 mo. | Not given | anal | 14% (unclear R/S) | 14% (unclear R/S) |
Ogino et al. [83] 2003 | 1983–1998 | 335 post-menopausal | 8 mo./39 mo. | 49.4 | cervical | 17% (R) | 18% (S) |
14% (S) | |||||||
Tai et al. [84] 2000 | 1991–1995 | 336 | 11 mo./29 mo. | Not given | endometrial vaginal | 4.8% (S) | 2.1% (S) |