Table 4 Canonical pathways enriched in genes differentially expressed between subtypes
Pathway | p-value | Overlap (%) | Overlap (gene number) |
|---|---|---|---|
MpBC vs. TNBC | |||
 Hepatic fibrosis /Hepatic stellate cell activation | 1.80E-03 | 39.3 | 11/28 |
 Atherosclerosis signaling | 2.13E-02 | 40 | 6/15 |
Mesenchymal vs. other MpBC | |||
 Interferon signaling | 6.83E-04 | 57.1 | 4/7 |
 Granulocyte adhesion and diapedesis | 1.18E-03 | 31.6 | 6/19 |
 Agranulocyte adhesion and diapedesis | 4.74E-03 | 29.4 | 5/17 |
 Type I Diabetes Mellitus signaling | 1.01E-02 | 42.9 | 3/7 |
 Th1 pathway | 1.01E-02 | 42.9 | 3/7 |
 Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F | 1.48E-02 | 66.7 | 2/3 |
 Th1 and Th2 activation pathway | 1.53E-02 | 37.5 | 3/8 |
 HMGB1 signaling | 1.77E-02 | 26.7 | 4/15 |
 Dendritic cell maturation | 1.77E-02 | 26.7 | 4/15 |
 IL-17 signaling | 2.19E-02 | 33.3 | 3/9 |
 iNOS signaling | 2.83E-02 | 50.0 | 2/4 |
 T helper cell differentiation | 2.83E-02 | 50.0 | 2/4 |
 Retinoic acid mediated apoptosis signaling | 2.83E-02 | 50.0 | 2/4 |
 IL-17A signaling in fibroblasts | 2.83E-02 | 50.0 | 2/4 |
 IL-15 production | 2.83E-02 | 50.0 | 2/4 |
 Production of nitric oxide and reactive oxygen species in macrophages | 2.97E-02 | 30.0 | 3/10 |
 LXR/RXR activation | 2.97E-02 | 30.0 | 3/10 |
 Hepatic fibrosis /Hepatic stellate cell activation | 4.28E-02 | 17.9 | 5/28 |
Spindle vs. other MpBC | |||
 Agranulocyte adhesion and diapedesis | 5.60E-05 | 41.2 | 7/17 |
 Granulocyte adhesion and diapedesis | 1.18E-03 | 31.6 | 6/19 |
 Role of IL-17F in allergic inflammatory airway diseases | 1.30E-03 | 50.0 | 4/8 |
 Role of IL-17A in Arthritis | 1.30E-03 | 50.0 | 4/8 |
 Glucocorticoid receptor signaling | 2.13E-03 | 28.6 | 6/21 |
 Osteoarthritis pathway | 4.74E-03 | 29.4 | 5/17 |
 Role of IL-17A in Psoriasis | 6.04E-03 | 50.0 | 3/6 |
 Hepatic fibrosis /Hepatic stellate cell activation | 1.04E-02 | 21.4 | 6/28 |
 Differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F | 1.48E-02 | 66.7 | 2/3 |
 Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F | 1.48E-02 | 66.7 | 2/3 |
 Airway pathology in Chronic Obstructive Pulmonary Disease | 1.48E-02 | 66.7 | 2/3 |
 IL-17A Signaling in airway cells | 1.53E-02 | 37.5 | 3/8 |
 IL-17A signaling in fibroblasts | 2.83E-02 | 50.0 | 2/4 |
 LXR/RXR activation | 2.97E-02 | 30.0 | 3/10 |
 TREM1 signaling | 3.89E-02 | 27.3 | 3/11 |
Squamous vs. other MpBC | |||
 No significant pathways to report |  |  |  |