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Table 4 Canonical pathways enriched in genes differentially expressed between subtypes

From: Pathway activity profiling of growth factor receptor network and stemness pathways differentiates metaplastic breast cancer histological subtypes

Pathway p-value Overlap (%) Overlap (gene number)
MpBC vs. TNBC
 Hepatic fibrosis /Hepatic stellate cell activation 1.80E-03 39.3 11/28
 Atherosclerosis signaling 2.13E-02 40 6/15
Mesenchymal vs. other MpBC
 Interferon signaling 6.83E-04 57.1 4/7
 Granulocyte adhesion and diapedesis 1.18E-03 31.6 6/19
 Agranulocyte adhesion and diapedesis 4.74E-03 29.4 5/17
 Type I Diabetes Mellitus signaling 1.01E-02 42.9 3/7
 Th1 pathway 1.01E-02 42.9 3/7
 Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F 1.48E-02 66.7 2/3
 Th1 and Th2 activation pathway 1.53E-02 37.5 3/8
 HMGB1 signaling 1.77E-02 26.7 4/15
 Dendritic cell maturation 1.77E-02 26.7 4/15
 IL-17 signaling 2.19E-02 33.3 3/9
 iNOS signaling 2.83E-02 50.0 2/4
 T helper cell differentiation 2.83E-02 50.0 2/4
 Retinoic acid mediated apoptosis signaling 2.83E-02 50.0 2/4
 IL-17A signaling in fibroblasts 2.83E-02 50.0 2/4
 IL-15 production 2.83E-02 50.0 2/4
 Production of nitric oxide and reactive oxygen species in macrophages 2.97E-02 30.0 3/10
 LXR/RXR activation 2.97E-02 30.0 3/10
 Hepatic fibrosis /Hepatic stellate cell activation 4.28E-02 17.9 5/28
Spindle vs. other MpBC
 Agranulocyte adhesion and diapedesis 5.60E-05 41.2 7/17
 Granulocyte adhesion and diapedesis 1.18E-03 31.6 6/19
 Role of IL-17F in allergic inflammatory airway diseases 1.30E-03 50.0 4/8
 Role of IL-17A in Arthritis 1.30E-03 50.0 4/8
 Glucocorticoid receptor signaling 2.13E-03 28.6 6/21
 Osteoarthritis pathway 4.74E-03 29.4 5/17
 Role of IL-17A in Psoriasis 6.04E-03 50.0 3/6
 Hepatic fibrosis /Hepatic stellate cell activation 1.04E-02 21.4 6/28
 Differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F 1.48E-02 66.7 2/3
 Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F 1.48E-02 66.7 2/3
 Airway pathology in Chronic Obstructive Pulmonary Disease 1.48E-02 66.7 2/3
 IL-17A Signaling in airway cells 1.53E-02 37.5 3/8
 IL-17A signaling in fibroblasts 2.83E-02 50.0 2/4
 LXR/RXR activation 2.97E-02 30.0 3/10
 TREM1 signaling 3.89E-02 27.3 3/11
Squamous vs. other MpBC
 No significant pathways to report    
  1. MpBC metaplastic breast cancer, TNBC invasive ductal carcinoma of triple negative breast cancer phenotype