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Table 1 Genetic characteristics and HER-2/HER-3 immunostaining of 12 CRC cell lines

From: Combined targeting of HER-2 and HER-3 represents a promising therapeutic strategy in colorectal cancer

Cell Line TP53 Mutation KRAS Mutation APC Mutation MMR Status HER-2 Mutation HER-2 ICC HER-3 ICC
HT29 + - + MSS - 1+ 3+
SW403 + + + MSS - 1+ 1+
SW837 + + + MSS - 2+ 1+
SW1116 + + + MSS - 2+ 3+
LS513 - + - MSS - 2+ 3+
LS1034 + + + MSS - 2+ 3+
Caco-2 + - + MSS - 2+ 1+
SW1463 + + + MSS - 1+ 3+
SW480 + + + MSS + 0 0
SW620 + + + MSS - 0 0
HCT116 - + - MSS - 0 0
LS411N + - + MSS + 2+ 1+
  1. MMR mismatch repair, MSI microsatellite-instable, MSS microsatellite-stable, ICC immunocytochemistry