Fig. 6

Lipid-laden human NK cells in colorectal cancer surgical patients have higher CD36, but lower Granzyme B and perforin expression and cytotoxicity. a Flow cytometry profiles of one representative patient (patient 1 from CIPO study). b MFI of BODIPY⁺ human NK cells (CD56⁺, CD3⁻) was evaluated in PBMC from colorectal cancer surgical patients at baseline (preoperative), POD1, POD3(±1) and POD28(±14). Proportion of blood Perforin⁺ (c), Granzyme B⁺ (d) and CD36⁺ (e) NK cells (CD56⁺, CD3⁻) was evaluated in PBMC from colorectal cancer surgical patients at baseline (preoperative), POD1, POD3(±1) and POD28(±14). f The ability of PBMC from colorectal cancer surgical patients at baseline (preoperative), POD1, POD3(±1) and POD28(±14) to kill K562 target cells was tested by ⁵¹Cr- release assay at 200:1 effector cell (PBMC) to target cell (K562) ratio. * Patient 4 is missing POD3