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Fig. 3 | BMC Cancer

Fig. 3

From: NPM1 as a potential therapeutic target for atypical teratoid/rhabdoid tumors

Fig. 3

Gene sets significantly enriched by differentially expressed genes in the AT/RT samples after gene set enrichment analysis (GSEA). Ten gene sets each were significantly enriched within the ‘Canonical pathway’ and ‘Cancer gene neighbor’ categories. Genes that are associated with cancer (based on the Genetic Association Database (GAD, https://geneticassociationdb.nih.gov/)) are mapped with gene sets by color code. Among the 261 genes annotated in GSEA, a total of 88 genes were also commonly annotated to the cancer class of the GAD. NPM1 was the most significant gene that was upregulated in AT/RTs and was found to be associated with the cell cycle in the canonical pathway

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