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Fig. 3 | BMC Cancer

Fig. 3

From: SMARC-B1 deficient sinonasal carcinoma metastasis to the brain with next generation sequencing data: a case report of perineural invasion progressing to leptomeningeal invasion

Fig. 3

Histologic findings of intracranial resection specimen. a. Sheets of highly atypical cells with open chromatin and prominent nucleoli, resembling nasopharyngeal undifferentiated carcinoma. b. Areas of necrosis and scattered cells with rhabdoid features are also seen. c. Many cells are positive for low-molecular weight cytokeratin (CK 8/18). d. Loss of nuclear INI-1 expression in the neoplastic cells, while it is retained in the endothelial cells (arrow). Inset: INI-1 control stain. (a and b: Hematoxylin and eosin; c and d: Immunohistochemistry. Original magnifications: a-d: 200 x)

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