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Fig. 2 | BMC Cancer

Fig. 2

From: SMARC-B1 deficient sinonasal carcinoma metastasis to the brain with next generation sequencing data: a case report of perineural invasion progressing to leptomeningeal invasion

Fig. 2

Histologic findings of initial biopsy specimen. a. A poorly-differentiated neoplasm with large epithelioid cells and mitotic activity (arrow) is seen. b. The neoplasm (bottom right) infiltrates the nerve fascicles (upper left). Many large, atypical cells (arrows) crowding the fascicle, which is represented by residual spindled Schwann cells, and several degenerating axons with myelin ovoids (arrowheads).c. Neurofilament protein immunohistochemistry highlights the axons that are widely separated from each other by infiltrating neoplastic cells. d. Cytokeratin shows the neoplasm to be a carcinoma encircling the nerve fascicle, with a group of infiltrating cells (arrow) within it. (a and b: Hematoxylin and eosin; c and d: Immunohistochemistry. Original magnifications: a and d: 200x; b and c: 400x)

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