Fig. 4
Comparison of the chemoresistance of ALI multilayered co- and mono-cultures. Percentage (%) of live A549 cells and cytotoxicity detected in ALI multilayered mono- and co-cultures exposed to four anti-cancer drugs (docetaxel, cytarabine, vinblastine and methotrexate) at their nominal IC50 concentration for 72 h, by direct inoculation or nebulization. Data are reported as average ± standard error of the mean (nreplicates = 2; ntests = 3). p values indicate significant differences (two-way ANOVA and Bonferroni post-test)