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Table 1 Characteristics of NPC patients and healthy controls

From: Genome-wide study of salivary microRNAs as potential noninvasive biomarkers for detection of nasopharyngeal carcinoma

Characteristics Discovery set (n = 47) Validation set (n = 16)
NPC patients (n = 22) healthy controls (n = 25) p value NPC patients (n = 8) healthy controls (n = 8) p value
Median age (y, range) 48 (25–68) 45 (25–65) 0.933 50 (20–69) 46 (26–61) 0.311
Gender    0.756    0.619
 Male 14 (63.6%) 16 (64.0%)   6 (75%) 5 (62.5%)  
 Female 8 (36.4%) 9 (36.0%)   2 (25%) 3 (37.5%)  
Smoking    0.713    0.642
 Yes 10 (45.5%) 10 (40.0%)   4 (50%) 5 (62.5%)  
 No 12 (54.5%) 15 (60.0%)   4 (50%) 3 (37.5%)  
Drinking    0.825    0.334
 Yes 3 (13.6%) 4 (16.0%)   1 (12.5%) 0  
 No 19 (86.4%) 21 (84.0%)   7 (87.5%) 8 (100%)  
Karnofsky performance score    0.129    0.334
 ≤ 80 2 (9.1%) 0   1 (12.5%) 0  
 ≥ 90 20 (90.9%) 25 (100/%)   7 (87.5%) 8 (100%)  
Pathology (WHO classification)
 Non-keratinizing (typeII-III) 22 (100.0%)    8 (100.0%)   
Pre-EBV DNA (copies/mL) Median (rang) 1,597,817 (0–59,200,000) 0 0.001 1,959,159 (0–2,860,000) 0 0.022
LDH (U/L) Median (range) 168 (102–684) 115 (101–298) 0.368 171 (116–339) 137 (102–274) 0.119
HGB(g/L) Median (range) 127 (81–169) 135 (121–168) 0.289 130 (93–172) 129 (117–148) 0.085
ALB(g/L) Median (range) 41.3 (30–55) 46 (37–56) 0.041 41 (34–56) 44 (38–55) 0.215
CRP (mg/L) Median (range) 2 (0–119.1) 1.2 (0–32) 0.025 8.1 (0–45.4) 2.3 (0–29) 0.063
T category a
 T1 6 (27.3%)    1 (12.5%)   
 T2 4 (18.2%)    1 (12.5%)   
 T3 5 (22.7%)    3 (37.5%)   
 T4 7 (31.8%)    3 (37.5%)   
N category a
 N0 1 (4.5%)    0   
 N1 6 (27.3%)    3 (37.5%)   
 N2 12 (54.6%)    4 (50.0%)   
 N3 3 (13.6%)    1 (12.5%)   
Overall stage a
 I 1 (4.5%)    0   
 II 5 (22.7%)    2 (25.0%)   
 III 6 (27.3%)    5 (50.0%)   
 IVA-B 10 (45.5%)    1 (12.5%)   
  1. Abbreviations: WHO world health organization, Pre-EBV DNA pre-treatment plasma Epstein-Barr Virus DNA, LDH lactate dehydrogenase, HGB hemoglobin, ALB albumin, CRP C-reaction protein
  2. aAccording to the 8th AJCC/UICC staging system