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Table 2 Concordance between the results of the 18 HPV MALDI-TOF MS and the Roche Cobas 4800 assays

From: Development of high-throughput genotyping method of all 18 HR HPV based on the MALDI-TOF MS platform and compared with the Roche Cobas 4800 HPV assay using clinical specimens

HPV genotype PCR-MS results Results of Cobas assay Concordance rate (%) Kappa coefficient 95% CI
Positive Negative Total
All Positive 129 42 171 80.1 0.60 0.52–0.69
Negative 29 156 185    
Total 158 198 356    
16 Positive 65 22 87 88.5 0.68 0.59–0.77
Negative 19 250 269    
Total 84 272 356    
18 Positive 5 3 8 98.9 0.71 0.17–0.94
Negative 1 347 348    
Total 6 350 356    
Other 12 HR HPVa Positive 57 32 89 82.6 0.53 0.40–0.62
Negative 30 237 267    
Total 87 269 356    
  1. aincluding HPV 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68