Development of high-throughput genotyping method of all 18 HR HPV based on the MALDI-TOF MS platform and compared with the Roche Cobas 4800 HPV assay using clinical specimens

Table 2 Concordance between the results of the 18 HPV MALDI-TOF MS and the Roche Cobas 4800 assays

HPV genotype	PCR-MS results	Results of Cobas assay			Concordance rate (%)	Kappa coefficient	95% CI
HPV genotype	PCR-MS results	Positive	Negative	Total	Concordance rate (%)	Kappa coefficient	95% CI
All	Positive	129	42	171	80.1	0.60	0.52–0.69
	Negative	29	156	185
	Total	158	198	356
16	Positive	65	22	87	88.5	0.68	0.59–0.77
	Negative	19	250	269
	Total	84	272	356
18	Positive	5	3	8	98.9	0.71	0.17–0.94
	Negative	1	347	348
	Total	6	350	356
Other 12 HR HPV^a	Positive	57	32	89	82.6	0.53	0.40–0.62
	Negative	30	237	267
	Total	87	269	356

ISSN: 1471-2407