Table 3 Plasma, organ, and tumor concentrations of MP1 in NSG mice dosed with 15 mg/kg MP1 five times per week orally. Samples collected at necropsy at 30 min or 24 h after dosing of MP1
Mouse ID | Time of collection | Plasma Conc (ng/mL) | Liver Conc (ng/g) | Lungs Conc (ng/g) | Tumor Conc (ng/g) | Spleen Conc (ng/g) | Fore Brain Conc (ng/g) | Mid Brain Conc (ng/g) | Hind Brain Conc (ng/g) |
|---|---|---|---|---|---|---|---|---|---|
BE-326 | 30 min | 571.2 | 4122.2 | 2154.6 | 1433.0 | AB | 52.0 | 167.3 | 72.6 |
BE-329 | 30 min | 244.6 | 2235.1 | 1053.2 | 2156.7 | 279.7 | 39.3 | 30.8 | 34.5 |
BE-330 | 30 min | 719.1 | 2627.7 | 1719.7 | 796.6 | 461.2 | 56.1 | 57.8 | 58.5 |
BE-327 | 24 h | 6.7 | 41.8 | 14.5 | 3.8 | AB | 0.5 | 0.6 | 0.7 |
BE-331 | 24 h | 12.2 | 30.6 | 11.9 | 2.3 | AB | 10.7 | 13.8 | 22.7 |
BE-332 | 24 h | 38.1 | 46.7 | 5.5 | 1.7 | 1.2 | 0.2 | 0.1 | 0.3 |