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Table 3 Plasma, organ, and tumor concentrations of MP1 in NSG mice dosed with 15 mg/kg MP1 five times per week orally. Samples collected at necropsy at 30 min or 24 h after dosing of MP1

From: Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus

Mouse ID Time of collection Plasma Conc (ng/mL) Liver Conc (ng/g) Lungs Conc (ng/g) Tumor Conc (ng/g) Spleen Conc (ng/g) Fore Brain Conc (ng/g) Mid Brain Conc (ng/g) Hind Brain Conc (ng/g)
BE-326 30 min 571.2 4122.2 2154.6 1433.0 AB 52.0 167.3 72.6
BE-329 30 min 244.6 2235.1 1053.2 2156.7 279.7 39.3 30.8 34.5
BE-330 30 min 719.1 2627.7 1719.7 796.6 461.2 56.1 57.8 58.5
BE-327 24 h 6.7 41.8 14.5 3.8 AB 0.5 0.6 0.7
BE-331 24 h 12.2 30.6 11.9 2.3 AB 10.7 13.8 22.7
BE-332 24 h 38.1 46.7 5.5 1.7 1.2 0.2 0.1 0.3
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