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Table 1 Cell cycle analysis in BE-2c cells using propidium iodide flow cytometry. Performed after 18 h of pre-treatment with MP1 at varying concentrations. Controls included media plus cells and vehicle

From: Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus

Group

%G1 Phase (SD)

%S Phase (SD)

%G2 Phase (SD)

Media Control

46.5 (5.2)

44.8 (4.6)

8.8 (1.7)

Vehicle

48.8 (5.6)

43.0 (5.9)

9.3 (1.5)

MP1 (0.25 μM)

64.5 (3.8)

28.8 (3.6)

6.8 (0.96)

MP1 (0.50 μM)

62.8 (6.7)

27.8 (3.1)

9.5 (3.7)

MP1 (1.0 μM)

50.3 (8.3)

31.3 (4.2)

18.3 (6.0)

MP1 (2.5 μM)

48.0 (7.4)

32.5 (5.1)

19.5 (6.9)

MP1 (5.0 μM)

48.5 (7.0)

32.8 (2.2)

18.0 (6.5)

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BMC Cancer

ISSN: 1471-2407

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