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Fig. 6 | BMC Cancer

Fig. 6

From: The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases

Fig. 6

PRDX1 acts as a gatekeeper of JNK activity in the transition of benign fibroblasts into CAFs under rising levels of H2O2. PRDX1 controls JNK activation under low H2O2 levels through protecting PTEN from inactivation by H2O2. As H2O2 levels rise, PRDX1 dissociates from PTEN resulting in reversible PTEN inactivation [29, 30] and JNK phosphorylation and activation [31]. Under these circumstances, PRDX1 binds associates with JNK and inhibits JNK activation. Therefore, it is proposed that PRDX1 controls JNK activity on two levels: first, by promoting PTEN activity and secondly, by binding directly to JNK

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