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Fig. 7 | BMC Cancer

Fig. 7

From: PLOD2 contributes to drug resistance in laryngeal cancer by promoting cancer stem cell-like characteristics

Fig. 7

PLOD2 overexpression could activate the Wnt signaling pathway. a The mRNA levels of downstream genes of the Wnt signaling pathway(c-myc, CD44, Snail, TCF4, and MMP-2) were upregulated by PLOD2. β-Actin was used as an internal control. b Dual luciferase assay showing the effect on TOP/FOP reporter activity in LSCC cells following the overexpression and silencing of PLOD2. c Immunoblot assay of c-myc, β-catenin, MDR-1, and MRP protein levels in LSCC cells transfected with PLOD2 and controls. GAPDH was used as an internal control

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BMC Cancer

ISSN: 1471-2407

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