Table 1 Chronicle of the diagnosis and treatment. HPV, human papillomavirus
Date | Procedures of diagnosis and treatment | Pathological findings |
|---|---|---|
September 1, 2011 | Vaginal biopsy | Vaginal adenosis |
December 16, 2011 | Vulvar biopsy | Chronic inflammation; absence of focal epithelial absence; granulation tissue formation |
March 4, 2013 | Cytology | A few atypical glandular cells and high-grade squamous intraepithelial lesion |
March 4, 2013 | High-risk HPV test | Negative |
April 10, 2013 | Vaginal and cervical biopsy | chronic inflammation; cervical intraepithelial neoplasia of grade I |
May 10, 2013 | Fractional curettage | Endometrium of late proliferative phase |
March 4, 2015 | Cytology | Atypical squamous cells: cannot exclude high-grade squamous intraepithelial lesion |
March 4, 2015 | Vaginal biopsy | Vaginal adenosis; moderate atypical hyperplasia of focal squamous epithelium |
December 24, 2015 | Cytology | A few atypical gland cells |
December 24, 2015 | High-risk HPV test | Negative |
March 18, 2016 | Cytology | Suspicious adenocarcinoma of cervix; atypical squamous epithelial cells of vagina |
March 3, 2016 | Fractional curettage | A little cervical canal tissue and endometrium of secretory phase |
April 15, 2016 | Vaginal biopsy | The serous papillary glands with active growth; chronic inflammation |
May 4, 2016 | Hysterectomy with bilateral salpingoophorectomy, and excision of vaginal lesions | Normal findings except atypical vaginal adenosis in the vaginal wall |
May 15, 2017 | Cytology | A few atypical gland cells |
May 15, 2017 | Biopsy of vaginal stump | Serous papillary glands with active growth, which suggested atypical adenosis |
August 15, 2017 | Excision of vaginal lesions | The mass of mid-anterior vaginal wall was confirmed to be clear cell carcinoma |
September 15, 2017 | Wide local resection of vaginal lesions | Atypical vaginal adenosis with negative incision margin |
July 18, 2018 | Biopsy of vulvar ulcer | Chronic inflammation of fibrous tissue and squamous epithelium |