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Table 2 Cases of gingival metastasis by hepatocellular carcinoma with survival data in reviewed literatures

From: Gingival metastasis from primary hepatocellular carcinoma: a case report and literature review of 30 cases

Case Number

Reference

Gender

Age

Gingival neoplasm as first sign

Metastasis besides gingiva

Lesion location on gingiva

Major lesion manifestation

Preexisting Hepatopathy

Differentiation Grade

Primary tumor therapy

Giginval tumor therapy

Truncated/Overall survival

18

Kuo, 2006

Male

57

Yes

Brain, Lung

Right Upper

Rapid enlarging

Post hepatitis B cirrhosis

Moderate

None

Resection

11/1 months

19

Rai, 2009

Male

82

Yes

None

Left Lower

Rapid enlarging

None

Poor

ND

ND

ND

20

Huang, 2009

Male

60

Yes

Right anterior chest wall

Right upper

Rapid enlarging

ND

Moderate

ND

ND

ND

21

Inaba, 2011

Male

80

No

Lungs

Right Lower

Uncontrolled Bleeding

Post hepatitis C cirrhosis

Poor

TAE

TAE

92/1 months

22

Poojary, 2011

Male

70

Yes

Lungs, Adrenal glands, Thoracic vertebra

Right Lower

Rapid enlarging

ND

Moderate

Palliative treatment

Palliative treatment

ND

23

Terada, 2011

Male

55

Yes

None

Upper Left

Bleeding

Post hepatitis C cirrhosis

High

Chemotherapy

Chemotherapy

ND

24

Greenstein, 2013

Male

68

No

Lungs

Central Upper

Continuous bleeding

Post hepatitis B cirrhosis

Moderate

Chemotherapy

Resection

ND

25

Gentile, 2013

Male

80

No

Lungs, Penis

Right Lower

Bleeding

ND

Moderate

Partial hepatectomy, Radiofrequency ablation, Chemotherapy

None

26/3 months

26

Chen, 2014

Male

58

No

Lungs, Renal

Right Upper to Left lateral

Rapid enlarging, Occasional bleeding

ND

Moderate

Partial hepatectomy, Chemotherapy

Chemotherapy, Radiotherapy

ND

27

Gong, 2015

Male

43

No

ND

Right Upper

ND

ND

Moderate

None

Resection

> 24/> 12 months

28

Kwon, 2016

Male

50

Yes

ND

Left Upper

Rapid enlarging, Bleeding, Pain

Post hepatitis B cirrhosis

Undifferentiation

None

None

2/1 weeks

29

Xue, 2017

Male

60

No

Lungs, Brain

Right Upper

Pain

Post hepatitis B cirrhosis

Poor

Chemotherapy, Sorafenib, TACE

Resection

13/2 months

30

Present case

Male

87

No

Lungs

Left Upper

Bleeding

Post hepatitis B cirrhosis

Moderate

None

None

3/2 months

  1. ND not described, LN lymph node, TACE transarterial chemoembolization, TAE transcatheter arterial embolization.
  2. ∗Truncated survival, the period from onset of gingival metastasis to death