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Fig. 8 | BMC Cancer

Fig. 8

From: Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane

Fig. 8

Bronchial carcinoid tumor patient-derived spheroids show high tumorigenic potential both orthotopically and subcutaneously. a Shows the gross morphology of normal lung (left) and the patient-derived orthotopic tumor (right) in lung (arrows); b H&E histology at lower and higher magnifications of the patient-derived tumor showing typical BC morphology and dense cellularity; c Immunofluorescence labeling for Chromogranin A (ChA) in patient derived orthotopic lung xenograft. DAPI counterstain for labeling of cell nuclei. d Gross morphology of patient derived subcutaneous xenografts (arrows) in mouse subinguinal region. e H&E histology of the resected subcutaneous xenograft; f Immunohistochemical staining for Chromogranin A in subcutaneous xenografts

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