Fig. 7

Spheroids developed from H727 and H720 were orthotopically heterotransplanted into mice lungs and formed foci of dense tumor cells. a H&E histology of normal lung versus H727 3rd generation SP cells orthotopically xenografted in mouse lungs and tumors allowed to developed over days. Arrows point to tumor masses in lung parenchyma. b Lung xenografts analyzed after treatments with AZ, SFN and AZ + SFN in 40 mg/Kg were assessed for number of tumor cells per high-powered field. Below: H&E histology of tumor fields in these treated mice comparing untreated, AZ, SFN and AZ + SFN treatments. c A similar experiment as in A&B was performed for H720 3rd generation SP cells orthotopically xenografted into mouse lung. c histology; d number of tumor cells per high powered field; Below: H&E histology on H720 3rd generation SP generated orthotopic tumors comparing control with AZ, SFN and AZ + SFN treatments