Table 3 Univariate and Multivariate Analysis by a Cox Proportional Hazards Regression Model in Cohort
Variable | OS | |||
|---|---|---|---|---|
Univariate | Multivariate | |||
HR (95% CI) | P Value | HR (95% CI) | P Value | |
Age, years (> 45 vs. ≤ 45) | 0.898 (0.581–1.390) | 0.630 | NA | |
ER (positive vs. negative) | 1.114 (0.711–1.745) | 0.637 | NA | |
PR (positive vs. negative) | 1.213 (0.775–1.899) | 0.398 | NA | |
CrebB-2 (positive vs. negative) | 1.128 (0.705–1.806) | 0.615 | NA | |
Menstrual history (presence vs. absence) | 1.381 (0.851–2.241) | 0.191 | NA | |
Operation | 0.649 | NA | ||
Modified radical mastectomy vs. radical correction | 1.150 (0.727–1.820) | 0.550 | NA | |
Other operation vs. radical correction | 0.642 (0.155–2.663) | 0.542 | NA | |
FADD (positive vs. negative) | 1.580 (0.995–2.509) | 0.053 | NA | |
NDRG1 (low vs. high) | 1.302 (0.762–2.226) | 0.335 | NA | |
CRYAB (positive vs. negative) | 1.561 (0.902–2.701) | 0.112 | NA | |
Tumor diameter, cm | 0.072 | NS | ||
> 5 vs. > 2 and ≤ 5 | 1.923 (1.019–3.636) | 0.043 | ||
> 5 vs. ≤2 | 2.230 (1.093–4.549) | 0.027 | ||
TNM stage | < 0.0001 | NS | ||
III vs. I | 4.329 (1.824–10.273) | 0.001 | ||
III vs. II | 2.101 (1.333–3.311) | 0.001 | ||
Histology stage (poorly differentiation vs. high-middle differentiation) | 2.286 (1.100–4.751) | 0.027 | NS | |
Histology type (lobular carcinoma vs. duct carcinoma) | 1.720 (1.025–2.886) | 0.040 | 1.846 (1.093–3.118) | 0.022 |
Lymph node metastasis (presence vs. absence) | 2.810 (1.694–4.662) | < 0.0001 | 2.801 (1.688–4.649) | < 0.0001 |
EpCAM (positive vs. negative) | 2.306 (1.218–4.367) | 0.010 | 2.585 (1.351–4.944) | 0.004 |