Table 4 Adjusted odds ratios for FN in cycle 1, cycle 2, cycles 3+, last cycle, and all cycles, respectively (Broad Definition of FN)
| Â | Adjusted Odds Ratio for FN (95% CI, p-value)* | ||||
|---|---|---|---|---|---|
Cycle 1 | Cycle 2 | Cycles ≥3 | Last Cycle | All Cycles | |
Commercial | |||||
 Independent Variables | |||||
  No PEG Prophylaxis | 2.6 (2.3–2.8, < 0.001) | 1.9 (1.6–2.2, < 0.001) | 1.5 (1.4–1.7, < 0.001) | 1.5 (1.4–1.7, < 0.001) | 2.1 (2.0–2.3, < 0.001) |
  FN in Prior Cycle | – | 3.2 (2.6–3.9, < 0.001) | 3.5 (3.2–4.0, < 0.001) | 2.4 (2.0–2.8, < 0.001) | 2.4 (2.2–2.6, < 0.001) |
  Regimen | |||||
   TAC | 2.9 (2.6–3.3, < 0.001) | 2.6 (1.7–4.1, < 0.001) | 1.7 (1.4–1.9, < 0.001) | 3.3 (2.4–4.8, < 0.001) | 2.7 (2.2–3.2, < 0.001) |
   TC | – | – | – | – | – |
   TCH | 1.1 (1.0–1.2, 0.229) | 2.2 (1.4–3.3, < 0.001) | 1.1 (1.0–1.2, 0.266) | 2.1 (1.5–2.9, < 0.001) | 1.4 (1.2–1.6, < 0.001) |
   CHOP±R | 1.3 (1.2–1.5, < 0.001) | 4.1 (1.9–9.0, < 0.001) | 1.7 (1.5–1.9, < 0.001) | 4.3 (2.4–7.7, < 0.001) | 2.6 (1.9–3.5, < 0.001) |
  Age | |||||
   18–49 | – | – | – | – | – |
   50–64 | 1.0 (0.9–1.1, 0.377) | 1.0 (0.9–1.2, 0.884) | 1.1 (1.0–1.2, 0.242) | 1.3 (1.1–1.4, 0.002) | 1.0 (1.0–1.1, 0.409) |
   65–74 | 1.3 (1.2–1.5, < 0.001) | 1.0 (0.8–1.2, 0.881) | 1.5 (1.3–1.8, < 0.001) | 1.7 (1.4–2.1, < 0.001) | 1.3 (1.2–1.4, < 0.001) |
   ≥ 75 | 1.7 (1.4–2.1, < 0.001) | 1.2 (0.9–1.7, 0.200) | 2.1 (1.8–2.6, < 0.001) | 3.4 (2.7–4.3, < 0.001) | 1.7 (1.5–2.0, < 0.001) |
Medicare | |||||
 Independent Variables | |||||
  No PEG Prophylaxis | 1.6 (1.5–1.7, < 0.001) | 1.6 (1.5–1.8, < 0.001) | 1.3 (1.3–1.4, < 0.001) | 1.0 (0.9–1.0, 0.507) | 1.5 (1.4–1.5, < 0.001) |
  FN in Prior Cycle | – | 3.2 (2.9–3.5, < 0.001) | 2.9 (2.7–3.1, < 0.001) | 1.7 (1.6–1.8, < 0.001) | 2.1 (2.1–2.2, < 0.001) |
  Regimen | |||||
   TAC | 2.5 (2.2–2.9, < 0.001) | 1.9 (1.5–2.4, < 0.001) | 2.0 (1.7–2.3, < 0.001) | 2.2 (1.9–2.6, < 0.001) | 2.1 (1.9–2.3, < 0.001) |
   TC | – | – | – | – | – |
   TCH | 0.8 (0.7–0.9, < 0.001) | 0.9 (0.8–1.0, 0.127) | 0.8 (0.7–0.9, < 0.001) | 1.0 (0.9–1.2, 0.387) | 0.8 (0.7–0.8, < 0.001) |
   CHOP±R | 1.5 (1.4–1.5, < 0.001) | 1.8 (1.7–2.0, < 0.001) | 1.9 (1.8–2.0, < 0.001) | 1.8 (1.7–2.0, < 0.001) | 1.6 (1.6–1.7, < 0.001) |
  Age | |||||
   65–74 | – | – | – | – | – |
   75–84 | 1.2 (1.1–1.3, < 0.001) | 1.0 (0.9–1.1, 0.709) | 1.1 (1.1–1.2, < 0.001) | 1.2 (1.1–1.3, < 0.001) | 1.1 (1.1–1.2, < 0.001) |
   ≥ 85 | 1.4 (1.3–1.5, < 0.001) | 1.2 (1.1–1.4, < 0.001) | 1.4 (1.3–1.5, < 0.001) | 1.8 (1.6–1.9, < 0.001) | 1.4 (1.3–1.4, < 0.001) |