Table 2 Clinical and Molecular Characteristics of patients with asymptomatic brain metastases

From: Combination therapy of brain radiotherapy and EGFR-TKIs is more effective than TKIs alone for EGFR-mutant lung adenocarcinoma patients with asymptomatic brain metastasis

	TKI + RT		TKI alone
Characteristic	(n = 23)	%	(n = 22)	%	p Value
Age (years)					0.608
Median	61		59
Range	44–75		41–74
< 65	14	60.9	15	68.2
≥65	9	39.1	7	31.8
Gender					0.295
Male	10	43.5	13	59.1
Female	13	56.5	9	40.9
Smoking history					0.295
Never or light	13	56.5	9	40.9
Heavy	10	43.5	13	59.1
EGFR mutation					0.155
Del19	12	52.2	16	72.7
L858r	11	47.8	6	27.3
Other	0	0	0	0
BM No. at time of diagnosis					0.463
≤3	14	60.9	11	50.0
>3	9	39.1	11	50.0
Extracranial metastases					0.477
Yes	18	78.3	19	86.4
No	5	21.7	3	13.6
Lung-mol GPA classification					0.266
0–1	0	0	0	0
1.5–2	3	13.1	6	27.3
2.5–3	13	56.5	10	45.4
3.5–4	7	30.4	6	27.3

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