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Table 2 Clinical and Molecular Characteristics of patients with asymptomatic brain metastases

From: Combination therapy of brain radiotherapy and EGFR-TKIs is more effective than TKIs alone for EGFR-mutant lung adenocarcinoma patients with asymptomatic brain metastasis

  TKI + RT TKI alone  
Characteristic (n = 23) % (n = 22) % p Value
Age (years)      0.608
 Median 61   59   
 Range 44–75   41–74   
 < 65 14 60.9 15 68.2  
 ≥65 9 39.1 7 31.8  
Gender      0.295
 Male 10 43.5 13 59.1  
 Female 13 56.5 9 40.9  
Smoking history      0.295
 Never or light 13 56.5 9 40.9  
 Heavy 10 43.5 13 59.1  
EGFR mutation      0.155
 Del19 12 52.2 16 72.7  
 L858r 11 47.8 6 27.3  
 Other 0 0 0 0  
BM No. at time of diagnosis      0.463
 ≤3 14 60.9 11 50.0  
 >3 9 39.1 11 50.0  
Extracranial metastases      0.477
 Yes 18 78.3 19 86.4  
 No 5 21.7 3 13.6  
Lung-mol GPA classification      0.266
 0–1 0 0 0 0  
 1.5–2 3 13.1 6 27.3  
 2.5–3 13 56.5 10 45.4  
 3.5–4 7 30.4 6 27.3  
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