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Table 3 CRC Performance by Validation Procedure

From: Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA

Validation Mean AUC (95% CI) Mean Sensitivity at 85% Specificity (95% CI)
k-fold 0.92 (0.91–0.93) 85% (83–86%)
Binned-age 0.91 (0.89–0.94) 79% (73–87%)
k-batch 0.91 (0.88–0.94) 85% (80–89%)
Ordered k-batch 0.90 (0.83–0.94) 73% (53–88%)
Balanced k-batch 0.83 (0.79–0.86) 71% (63–76%)
  1. CRC performance by cross-validation procedure in 50–84 year-old patients. Confidence intervals are calculated from bootstrapped distributions of the metric across folds