|
Confounder
|
k-fold CV AUC (95% CI)
|
k-fold CV Sensitivity at 85% Specificity (95% CI)
|
Confounder CV method
|
Confounder CV AUC (95% CI)
|
|---|
|
Age
|
0.71 (0.64–0.77)
|
44% (29–57%)
|
Binned-age
|
0.50 (0.50–0.50)
|
|
Batch
|
0.72 (0.69–0.75)
|
43% (31–53%)
|
k-batch
|
0.50 (0.50–0.50)
|
|
Processing Date
|
0.69 (0.64–0.74)
|
38% (25–49%)
|
Ordered k-batch
|
0.48 (0.43–0.52)
|
|
Institution
|
0.87 (0.84–0.90)
|
74% (72–77%)
|
Balanced k-batch
|
0.51 (0.28–0.74)
|
- Performance evaluation of known confounders alone to predict cancer with either k-fold or the CV procedure designed to control for the confounder. Confidence intervals are calculated from bootstrapped distributions of the metric across folds
