Table 2 Correlation between p-PKCι and p-PKCζ immunohistochemical expression and the clinicopathological features of LAC patients
Characteristics | Patients | p-PKCι | Patients | p-PKCζ | ||||
|---|---|---|---|---|---|---|---|---|
No. (%) | Low | High | P | No. (%) | Low | High | P | |
Sex | 0.736 | 0.880 | ||||||
Male | 105 (53) | 65 (52) | 40 (54) | 105 (53) | 63 (53) | 42 (52) | ||
Female | 95 (48) | 61 (48) | 34 (46) | 95 (48) | 56 (47) | 39 (48) | ||
Age | 0.061 | 0.777 | ||||||
< 60 | 59 (30) | 43 (34) | 16 (22) | 59 (26) | 36 (30) | 23 (28) | ||
≥ 60 | 141 (71) | 82 (66) | 58 (78) | 141 (71) | 83 (70) | 58 (72) | ||
Pathological stage | 0.039 | 0.423 | ||||||
I-II | 168 (84) | 111 (88) | 57 (77) | 168 (84) | 102 (86) | 66 (82) | ||
III-IV | 32 (16) | 15 (12) | 17 (23) | 32 (16) | 17 (14) | 15 (19) | ||
Histological subtype | 0.005 | 0.000 | ||||||
Acinar | 157 (79) | 91 (72) | 66 (89) | 157 (79) | 83 (70) | 74 (91) | ||
Lepidic | 43 (22) | 35 (28) | 8 (11) | 43 (22) | 36 (30) | 7 (8) | ||
Distant metastasis | 0.028 | 0.057 | ||||||
Absent | 188 (94) | 122 (97) | 66 (89) | 188 (94) | 115 (97) | 73 (90) | ||
Present | 12 (6) | 4 (3) | 8 (11) | 12 (6) | 4 (3) | 8 (10) | ||
Chemotherapy | 0.061 | 0.618 | ||||||
Not done | 130 (65) | 88 (70) | 42 (57) | 130 (65) | 79 (66) | 51 (63) | ||
Done | 70 (35) | 38 (30) | 32 (43) | 70 (35) | 40 (34) | 30 (37) | ||
EGFR | 0.439 | 0.637 | ||||||
Wild | 106 (57) | 63 (55) | 43 (61) | 106 (57) | 59 | 47 | ||
Mutant | 80 (43) | 52 (45) | 28 (39) | 80 (43) | 47 | 33 | ||